Recombinant Human OSMR / IL31RB Protein (His tag)

• Catalog number
  PKSH031191-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  IL-31RB;OSMRB;PLCA1
• Activity
  NA
• Sequence
  Met 1-Met 740
• Fusion tag
  C-His
• Accession
  NP_003990.1
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞96 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  82.6 kDa
• AP Mol Mass
  130-140 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor (OSMR) and Interleukin-31 receptor subunit beta (IL-31RB), is one of the receptor proteins for oncostatin M. OSMR is a member of the type I cytokine receptor family. IL-31RB/OSMR heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in IL-31RB/OSMR have been associated with familial primary localized cutaneous amyloidosis. Defects in IL-31RB/OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1), also known as familial lichen amyloidosis or familial cutaneous lichen amyloidosis. PLCA1 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.
• Technical data
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  OSMR   IL31RB   Protein   His   tag  
• Gene symbol
  OSMR-DT, OSMR
• Short name
  Recombinant OSMR / IL31RB Protein (His tag)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens oncostatin M receptor / IL31RB Protein (histidine detection labelled)
• Alternative technique
  rec
• Alternative to gene target
  oncostatin M receptor, OSMRB and PLCA1, OSMR and IDBG-17615 and ENSG00000145623 and 9180, growth factor binding, multiple, Osmr and IDBG-128241 and ENSMUSG00000022146 and 18414, BT.103407 and IDBG-629972 and ENSBTAG00000033107 and 514720

Gene info

• Identity
  HGNC:50296
• Gene
  OSMR-DT
• Long gene name
  OSMR divergent transcript
• Synonyms gene
  • OSMR-AS1
• Synonyms gene name
  • OSMR antisense RNA 1 (head to head)
• Locus
  5p13.1
• Discovery year
  2014-04-03
• Entrez gene record
  101929768
• RefSeq identity
  • NR_109951
• Classification
  • Divergent transcripts
• VEGA ID
  OTTHUMG00000162040

Gene info

• Identity
  HGNC:8507
• Gene
  OSMR
• Long gene name
  oncostatin M receptor
• Synonyms
  • OSMRB
  • OSMRbeta
• Synonyms name
  • Oncostatin-M-specific receptor subunit beta
• GenBank acession
  • U60805
• Locus
  5p13.1
• Discovery year
  1999-02-17
• Entrez gene record
  9180
• Pubmed identfication
  • 8999038
• RefSeq identity
  • NM_003999
• Classification
  • Fibronectin type III domain containing
• VEGA ID
  OTTHUMG00000090811

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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