Recombinant Human Neuropilin 2 / NRP2 Protein (Fc tag)

• Catalog number
  PKSH031480-20µg
• Price
  Please ask
• Size
  20µg

• Synonym
  Neuropilin-2;NP2;NPN2;PRO2714;VEGF165R2
• Activity
  Measured by its binding ability in a functional ELISA.2.Immobilized human VEGFC-His (Cat:10542-H08H) at 10μg/mL (100μL/well) can bind human NRP2-Fc (Cat:10695-H02H), the EC50 of human NRP2-Fc is 0.1-0.5μg/mL.
• Sequence
  Met1-Tyr855
• Fusion tag
  C-Fc
• Accession
  NP_003863.2
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞95 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  120.7 kDa
• AP Mol Mass
  119-129 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I? transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation factor V/VIII homology domains, and a MAM (meprin, tyrosine phosphatase domain) region. NRP-2 is a receptor capable of binding two disparate ligands, classⅢ semaphorins (SEMA) and vascular endothelial growth factors (VEGF), and thus regulates two diverse systems by activating cellular signaling pathways via interacting with other cell surface receptors such as VEGF receptors and plexins. NRP-2 is well known for its role in facilitating axonal guidance during the development of the neuronal system, and additionally, it is also expressed in vascular endothelial cells and lymphatic endothelium where it affects proliferation, migration, angiogenesis, as well as formation of small lymphatic vessels and capillaries. Recent study has identified NRP-2 as a polysialylated protein expressed in human dendritic cells and modulates DC-T cell Interactions. Nearly all tumor cells express neuropilins and NRP-2 is predominantly expressed in neuronal tumors and melanomas. Furthermore, it is suggested that as the specific ligand for NRP-2, SEMA 3F inhibits tumor angiogenesis and metastasis.
• Technical data
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Neuropilin   NRP2   Protein   tag  
• Gene symbol
  NRP2, NELL2
• Short name
  Recombinant Neuropilin 2 / NRP2 Protein (Fc tag)
• Technique
  Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  Fc Tag
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens Neuropilin 2 / neuropilin 2 Protein (fragment c detection labelled)
• Alternative technique
  rec
• Alternative to gene target
  neuropilin 2, NP2 and NPN2 and PRO2714 and VEGF165R2, NRP2 and IDBG-79320 and ENSG00000118257 and 8828, metal ion binding, Extracellular, Nrp2 and IDBG-160044 and ENSMUSG00000025969 and 18187, NRP2 and IDBG-643390 and ENSBTAG00000011971 and 541004

Gene info

• Identity
  HGNC:8005
• Gene
  NRP2
• Long gene name
  neuropilin 2
• Synonyms
  • VEGF165R2
• GenBank acession
  • AF016098
• Locus
  2q33.3
• Discovery year
  1998-12-23
• Entrez gene record
  8828
• Pubmed identfication
  • 9529250
  • 9331348
• VEGA ID
  OTTHUMG00000132893

Gene info

• Identity
  HGNC:7751
• Gene
  NELL2
• Long gene name
  neural EGFL like 2
• Synonyms gene name
  • nel (chicken)-like 2
  • NEL-like 2 (chicken)
• Synonyms
  • NRP2
• GenBank acession
  • D83018
• Locus
  12q12
• Discovery year
  1996-07-17
• Entrez gene record
  4753
• Pubmed identfication
  • 8975702
  • 25537860
• RefSeq identity
  • NM_006159
• VEGA ID
  OTTHUMG00000169464

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

Similar products