Recombinant Human KLK-8 / Kallikrein-8 Protein (His tag) 20µg

• Catalog number
  PKSH030307-20µg
• Price
  Please ask
• Size
  20µg

• Synonym
  HNP;NP;NRPN;PRSS19;TADG14
• Activity
  Measured by its ability to cleave the fluorogenic peptide substrate BocVPRAMC. The specific activity is > 400pmoles/min/μg
• Sequence
  Met 1-Gly 260
• Fusion tag
  C-His
• Accession
  O60259-1
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞98 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  26.4 kDa
• AP Mol Mass
  36 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Reconstitution
  Please refer to it for detailed information.
• Background
  Kallikrein-8, also known as Neuropsin, Serine protease 19, Serine protease TADG-14, Tumor-associated differentially expressed gene 14 protein and KLK8, is a secreted protein which belongs to the peptidase S1 family and Kallikrein subfamily. It is a serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Kallikrein-8 / KLK8 plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway. It regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. It is involved in skin desquamation and keratinocyte proliferation and plays a role in the secondary phase of pathogenesis following spinal cord injury. It also cleaves L1CAM in response to increased neural activity. It induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Kallikrein-8 / KLK8 is expressed at high levels in serum, ascites fluid and tumor cytosol of advanced stage ovarian cancer patients and may serve as a marker of ovarian cancer. Kallikrein-8 / KLK8 may have potential clinical value for disease diagnosis or prognosis and it may also be a useful therapeutic target.
• Product URL
• PDF URL
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  KLK-8   Kallikrein-8   Protein   His   tag   20µg  
• Gene symbol
  KLK14, KLK9, KLK12, KLK13, SNORD114-8, RNU6-8, KLK5, SNORD113-8, KLK8, SNORD116-8
• Short name
  Recombinant KLK-8 / Kallikrein-8 Protein (His tag) 20µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens KLK-8 / Kallikrein-8 Protein (histidine detection labelled) 20µg
• Alternative technique
  rec

Gene info

• Identity
  HGNC:6362
• Gene
  KLK14
• Long gene name
  kallikrein related peptidase 14
• Synonyms gene name
  • kallikrein 14
• Synonyms
  • KLK-L6
• GenBank acession
  • AF283670
• Locus
  19q13.41
• Discovery year
  2000-03-16
• Entrez gene record
  43847
• Pubmed identfication
  • 16800724
  • 16800723
• RefSeq identity
  • NM_022046
• Classification
  • Kallikreins
• VEGA ID
  OTTHUMG00000143721

Gene info

• Identity
  HGNC:6370
• Gene
  KLK9
• Long gene name
  kallikrein related peptidase 9
• Synonyms gene name
  • kallikrein 9
• Synonyms
  • KLK-L3
• GenBank acession
  • AF135026
• Locus
  19q13.41
• Discovery year
  2000-03-16
• Entrez gene record
  284366
• Pubmed identfication
  • 16800724
  • 16800723
• RefSeq identity
  • NM_012315
• Classification
  • Kallikreins
• VEGA ID
  OTTHUMG00000183087

Gene info

• Identity
  HGNC:6360
• Gene
  KLK12
• Long gene name
  kallikrein related peptidase 12
• Synonyms gene name
  • kallikrein 12
• Synonyms
  • KLK-L5
• Locus
  19q13.41
• Discovery year
  2000-03-16
• Entrez gene record
  43849
• Pubmed identfication
  • 16800724
  • 16800723
• RefSeq identity
  • NM_019598
• Classification
  • Kallikreins
• VEGA ID
  OTTHUMG00000165806

Gene info

• Identity
  HGNC:6361
• Gene
  KLK13
• Long gene name
  kallikrein related peptidase 13
• Synonyms gene name
  • kallikrein 13
• Synonyms
  • KLK-L4
• Locus
  19q13.41
• Discovery year
  2000-03-16
• Entrez gene record
  26085
• Pubmed identfication
  • 16800724
  • 16800723
• RefSeq identity
  • NM_015596
• Classification
  • Kallikreins
• VEGA ID
  OTTHUMG00000182912

Gene info

• Identity
  HGNC:32996
• Gene
  SNORD114-8
• Long gene name
  small nucleolar RNA, C/D box 114-8
• Synonyms
  • 14q(II-8)
• Locus
  14q32.31
• Discovery year
  2006-09-26
• Entrez gene record
  767584
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003200.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:34285
• Gene
  RNU6-8
• Long gene name
  RNA, U6 small nuclear 8
• Synonyms
  • U6-8
• Locus
  14q12
• Discovery year
  2008-06-10
• Entrez gene record
  101954278
• Pubmed identfication
  • 12711679
• RefSeq identity
  • NR_104088
• Classification
  • Small nuclear RNAs

Gene info

• Identity
  HGNC:6366
• Gene
  KLK5
• Long gene name
  kallikrein related peptidase 5
• Synonyms gene name
  • kallikrein 5
• Synonyms
  • SCTE
  • KLK-L2
• GenBank acession
  • AF135028
• Locus
  19q13.41
• Discovery year
  2000-03-16
• Entrez gene record
  25818
• Pubmed identfication
  • 10514489
  • 10608802
  • 16800724
  • 17012259
• RefSeq identity
  • NM_012427
• Classification
  • Kallikreins
• VEGA ID
  OTTHUMG00000183097

Gene info

• Identity
  HGNC:32987
• Gene
  SNORD113-8
• Long gene name
  small nucleolar RNA, C/D box 113-8
• Synonyms
  • 14q(I-8)
• Locus
  14q32.31
• Discovery year
  2006-09-20
• Entrez gene record
  767568
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003236.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:6369
• Gene
  KLK8
• Long gene name
  kallikrein related peptidase 8
• Synonyms gene
  • PRSS19
• Synonyms gene name
  • kallikrein 8 (neuropsin/ovasin)
• Synonyms
  • HNP
  • TADG14
  • neuropsin
  • ovasin
• GenBank acession
  • AB008390
• Locus
  19q13.41
• Discovery year
  1999-09-09
• Entrez gene record
  11202
• Pubmed identfication
  • 10102990
  • 9714609
  • 16800724
  • 16800723
• RefSeq identity
  • NM_007196
• Classification
  • Kallikreins
  • Serine proteases
• VEGA ID
  OTTHUMG00000183086

Gene info

• Identity
  HGNC:33074
• Gene
  SNORD116-8
• Long gene name
  small nucleolar RNA, C/D box 116-8
• Synonyms
  • HBII-85-8
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033420
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003323
• Classification
  • Small nucleolar RNAs, C/D box

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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