Recombinant Human FOLR2 / FBP Protein (His tag)

  • Catalog number
    PKSH031199-50µg
  • Price
    Please ask
  • Size
    50µg
  • Synonym
    BETA-HFR;FBP;FBP/PL-1;FR-BETA;FR-P3
  • Activity
    NA
  • Sequence
    Met 1-His 228
  • Fusion tag
    C-His
  • Accession
    P14207-1
  • Expressed Host
    HEK293 Cells
  • Shipping
    In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
  • Purity
    >87 % as determined by SDS-PAGE
  • Endotoxin
    <1.0 EU per µg as determined by the LAL method
  • Stability and Storage
    Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Mol Mass
    26 kDa
  • AP Mol Mass
    30-35 kDa
  • Formulation
    Lyophilized from sterile PBS, pH 7.4
  • Background
    Folate receptor beta, also known as Folate receptor 2, FBP, and FOLR2, is a member of the folate receptor family. FOLR2 is expressed in placenta and hematopoietic cells. The expression of FOLR2 is increased in malignant tissues. Members of the Folate receptor family members (FOLRs) have a high affinity for folic acid and for several reduced folic acid derivatives. They mediate the delivery of 5-methyltetrahydrofolate to the interior of, out of within, or between cells in a process known as potocytosis. FOLR2 has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages.
  • Conjugation
    histidine
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
    FOLR2   FBP   Protein   His   tag  
  • Gene symbol
    FOLR2, FBP1, FUBP1, RAB14, PRPF40A
  • Short name
    Recombinant FOLR2 / FBP Protein (His tag)
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
  • Label
    His
  • Species
    Human, Humans
  • Alternative name
    Rec. H. sapiens FOLR2 / FBP Protein (histidine detection labelled)
  • Alternative technique
    rec
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    fructose-bisphosphatase 1
  • Synonyms gene
  • Synonyms gene name
    • fructose-1,6-bisphosphatase 1
  • GenBank acession
  • Locus
  • Discovery year
    1993-08-19
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Fructose-1,6-bisphosphatases
  • VEGA ID
Gene info
Gene info
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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