Recombinant Human FOLR2 / FBP Protein (His tag)
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Catalog numberPKSH031199-50µg
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PricePlease ask
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Size50µg
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SynonymBETA-HFR;FBP;FBP/PL-1;FR-BETA;FR-P3
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ActivityNA
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SequenceMet 1-His 228
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Fusion tagC-His
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AccessionP14207-1
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Expressed HostHEK293 Cells
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ShippingIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity>87 % as determined by SDS-PAGE
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Endotoxin<1.0 EU per µg as determined by the LAL method
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Stability and StorageSamples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass26 kDa
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AP Mol Mass30-35 kDa
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FormulationLyophilized from sterile PBS, pH 7.4
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BackgroundFolate receptor beta, also known as Folate receptor 2, FBP, and FOLR2, is a member of the folate receptor family. FOLR2 is expressed in placenta and hematopoietic cells. The expression of FOLR2 is increased in malignant tissues. Members of the Folate receptor family members (FOLRs) have a high affinity for folic acid and for several reduced folic acid derivatives. They mediate the delivery of 5-methyltetrahydrofolate to the interior of, out of within, or between cells in a process known as potocytosis. FOLR2 has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages.
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Conjugationhistidine
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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SourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolFOLR2, FBP1, FUBP1, RAB14, PRPF40A
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Short nameRecombinant FOLR2 / FBP Protein (His tag)
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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LabelHis
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SpeciesHuman, Humans
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Alternative nameRec. H. sapiens FOLR2 / FBP Protein (histidine detection labelled)
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Alternative techniquerec
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Gene info
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Identity
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Gene
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Long gene namefolate receptor beta
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Synonyms gene name
- folate receptor 2 (fetal)
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Synonyms
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GenBank acession
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Locus
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Discovery year1992-04-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namefructose-bisphosphatase 1
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Synonyms gene
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Synonyms gene name
- fructose-1,6-bisphosphatase 1
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GenBank acession
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Locus
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Discovery year1993-08-19
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Fructose-1,6-bisphosphatases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namefar upstream element binding protein 1
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Synonyms gene
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Synonyms gene name
- far upstream element (FUSE) binding protein 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1999-01-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameRAB14, member RAS oncogene family
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-09-14
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- RAB, member RAS oncogene GTPases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namepre-mRNA processing factor 40 homolog A
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Synonyms gene
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Synonyms gene name
- formin-binding protein 3
- formin binding protein 3
- PRP40 pre-mRNA processing factor 40 homolog A (yeast)
- PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
- PRP40 pre-mRNA processing factor 40 homolog A
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-08-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Spliceosomal A complex
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data