Recombinant Human Endoglin / CD105 / ENG Protein (Fc tag) 50µg
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Catalog number
PKSH031832-50µg
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Price
Please ask
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Size
50µg
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Synonym
END;HHT1;ORW1
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Activity
Measured by its ability to bind biotinylated Human TGFRB1 in a functional ELISA.2. Measured by its ability to bind biotinylated Human ALK1-Fc in functional Elisa.
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Sequence
Met 1-Gly 586
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Fusion tag
C-Fc
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Accession
NP_001108225.1
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Expressed Host
HEK293 Cells
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Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity
>95 % as determined by SDS-PAGE
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Endotoxin
<1.0 EU per µg as determined by the LAL method
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Stability and Storage
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass
87.5 kDa
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AP Mol Mass
115-120 kDa
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Formulation
Lyophilized from sterile PBS, pH 7.4
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Reconstitution
Please refer to it for detailed information.
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Background
Endoglin, also known as CD105, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type I I receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
ENG
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Short name
Recombinant Endoglin / CD105 / ENG Protein (Fc tag) 50µg
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Technique
Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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Label
Fc Tag
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Species
Human, Humans
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Alternative name
Rec. H. sapiens Endoglin / CD105 / endoglin Protein (fragment c detection labelled) 50µg
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Alternative technique
rec
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Alternative to gene target
endoglin, END and HHT1 and ORW1, ENG and IDBG-86582 and ENSG00000106991 and 2022, transforming growth factor beta receptor, nuclei, Eng and IDBG-160783 and ENSMUSG00000026814 and 13805, ENG and IDBG-639059 and ENSBTAG00000008997 and 615844
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Gene info
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Identity
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Gene
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Long gene name
endoglin
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Synonyms gene
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Synonyms gene name
- Osler-Rendu-Weber syndrome 1
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Synonyms
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GenBank acession
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Locus
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Discovery year
1993-03-03
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Entrez gene record
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Pubmed identfication
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Classification
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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