ICAD, Recombinant Human (DFF 1, DFF 45, DFF alpha, DFF1, DFF35, DFF45, DFFA, DNA Fragmentation Factor alpha subunit, Inhibitor of Caspase Activated DNase)
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Catalog number
MBS637762
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Price
Please ask
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Size
0.1 mg
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Products_type
Recombinant Protein
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Products_short_name
[ICAD Human]
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Other_names
[IcaD]
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Purity
Affinity Purified>90% (SDS-PAGE) Purified by immunoaffinity chromatography.
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Form
Supplied as liquid in 20mM Tris-HCl buffer, pH 8.0, 10% glycerol, 1mM DTT.
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Concentration
1mg/ml
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Storage_stability
Maybe stored at 4 degree C for short term only. Aliquot to avoid repeated freezeing and thawing. Store at -20 degree C. Aliquots are stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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Description
The ICAD, Recombinant (DFF 1, DFF 45, DFF alpha, DFF1, DFF35, DFF45, DFFA, DNA Fragmentation Factor alpha subunit, Inhibitor of Caspase Activated DNase) is a α- or alpha protein sometimes glycoprotein present in blood. Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways. Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
DFFA, DFFB, PRKDC, HLA-DOA
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Short name
ICAD, Recombinant (DFF 1, DFF 45, DFF alpha, DFF1, DFF35, DFF45, DFFA, DNA Fragmentation Factor alpha subunit, Inhibitor of Caspase Activated DNase)
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Technique
Recombinant, dna, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. MyBioSource advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Species
Human, Humans
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Alternative name
ICAD, Rec. H. sapiens (DFF 1, DFF 45, DFF a, DFF1, DFF35, DFF45, Desoxyribonucleic acid fragmentation factor, 45kDa, alpha polypeptide, Desoxyribonucleic acid Fragmentation Factor a functionnal sequence, suppressor on caspase Activated DNase)
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Alternative technique
rec
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Alternative to gene target
DNA fragmentation factor, 45kDa, alpha polypeptide, DFF-45 and DFF1 and ICAD, DFFA and IDBG-89047 and ENSG00000160049 and 1676, protein binding, nuclei, Dffa and IDBG-204894 and ENSMUSG00000028974 and 13347
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Gene info
Gene info
Gene info
Gene info
MeSH Data
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Name
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Concept
Scope note:
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
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Tree numbers
Product images
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