Recombinant Human Coxsackievirus and Adenovirus Receptor/CAR/CXADR (C-6His)

• Catalog number
  C332-500
• Price
  Please ask
• Size
  500 ug

• Description
  Recombinant Human Coxsackievirus and Adenovirus Receptor is produced by our Mammalian expression system and the target gene encoding Leu20-Gly237 is expressed with a 6His tag at the C-terminus.
• Species reactivity
  Human
• Origin
  Human cells
• Peptide sequence
  LSITTPEEMIEKAKGETAYLPCKFTLSPEDQGPLDIEWLISPADNQKVDQVIILYSGDKIYDDYYPDLKGRVHFTSNDLKSGDASINVTNLQLSDIGTYQCKVKKAPGVANKKIHLVVLVKPSGARCYVDGSEEIGSDFKIKCEPKEGSLPLQYEWQKLSDSQKMPTSWLAEMTSSVISVKNASSEYSGTYSCTVRNRVGSDQCLLRLNVVPPSNKAGVDHHHHHH
• Estimated molecular weight
  25,08 kDa
• Protein purity
  Greater than 95% as determined by reducing SDS-PAGE.
• Endotoxin level
  Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
• Shipping condition
  Ambient/Room Temperature
• Package form
  Lyophilized from a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
• Storage conditions
  Lyophilized protein should be stored at below -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at below -20°C for 3 months.
• Reconstitution conditions
  Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 µg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• UniProt number
  P78310
• Other related products
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional description
  The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Coxsackievirus   Adenovirus   Receptor/CAR/CXADR   C-6His  
• Gene symbol
  CXADR, CXADRP1, NR1I3, SPG7
• Short name
  Recombinant Coxsackievirus Adenovirus Receptor/CAR/CXADR (C-6His)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. novo advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Human CAR/CXADR(C-6His)
• Alternative technique
  rec
• Alternative to gene target
  coxsackie virus and adenovirus receptor, CAR and CAR4/6 and HCAR, CXADR and IDBG-854 and ENSG00000154639 and 1525, connexin binding, nuclei, Gm1123 and IDBG-192613 and ENSMUSG00000044860 and 382097, CXADR and IDBG-630474 and ENSBTAG00000004869 and 281733
• Virus
  adenovirus

Gene info

• Identity
  HGNC:2559
• Gene
  CXADR
• Long gene name
  CXADR Ig-like cell adhesion molecule
• Synonyms gene name
  • coxsackie virus and adenovirus receptor
  • CXADR, Ig-like cell adhesion molecule
• Synonyms
  • CAR
• GenBank acession
  • Y07593
• Locus
  21q21.1
• Discovery year
  1998-03-24
• Entrez gene record
  1525
• Pubmed identfication
  • 9036860
  • 9096397
  • 20813955
• Classification
  • IgCAM CXADR-related subfamily
  • V-set domain containing
• VEGA ID
  OTTHUMG00000074508

Gene info

• Identity
  HGNC:23770
• Gene
  CXADRP1
• Long gene name
  CXADR pseudogene 1
• Synonyms gene name
  • coxsackie virus and adenovirus receptor pseudogene 1
• Synonyms
  • CAR
  • CXADRP
• Locus
  21q11.2
• Discovery year
  2008-01-31
• Entrez gene record
  653108
• VEGA ID
  OTTHUMG00000074204

Gene info

• Identity
  HGNC:7969
• Gene
  NR1I3
• Long gene name
  nuclear receptor subfamily 1 group I member 3
• Synonyms gene name
  • nuclear receptor subfamily 1, group I, member 3
• Synonyms
  • MB67
  • CAR1
  • CAR
• Synonyms name
  • constitutive androstane receptor
• GenBank acession
  • Z30425
• Locus
  1q23.3
• Discovery year
  1999-09-23
• Pubmed identfication
  • 8114692
• Classification
  • Nuclear receptor subfamily 1 group I
• VEGA ID
  OTTHUMG00000034347

Gene info

• Identity
  HGNC:11237
• Gene
  SPG7
• Long gene name
  SPG7 matrix AAA peptidase subunit, paraplegin
• Synonyms gene
  • CMAR
• Synonyms gene name
  • cell matrix adhesion regulator
  • spastic paraplegia 7 (pure and complicated autosomal recessive)
• Synonyms
  • CAR
  • SPG5C
• Synonyms name
  • paraplegin
• GenBank acession
  • Y16610
• Locus
  16q24.3
• Discovery year
  1998-06-25
• Entrez gene record
  6687
• Pubmed identfication
  • 9635427
  • 9634528
• RefSeq identity
  • NM_003119
• Classification
  • AAA ATPases
• VEGA ID
  OTTHUMG00000138046
• Locus Specific Databases
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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