Recombinant Human CNTFR / CNTFR-alpha Protein (His tag) 100µg

• Catalog number
  PKSH031308-100µg
• Price
  Please ask
• Size
  100µg

• Synonym
  CNTFR;MGC1774
• Activity
  Measured by its binding ability in a functional ELISA. Immobilized human CTNFR at 10 μg/ml (100 μl/well) can bind biotinylated human CNTF with a linear ranger of 1.28-160 ng/ml.
• Sequence
  Met 1-Pro 346
• Fusion tag
  NA
• Accession
  NP_001833.1
• Expressed Host
  Baculovirus-Insect Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞98 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  36 kDa
• AP Mol Mass
  45-48 kDa
• Formulation
  Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 8.0
• Reconstitution
  Please refer to it for detailed information.
• Background
  Ciliary neurotrophic factor(CNTF) is a member of the cytokine family. It is a polypeptide hormone that have functions in promoting neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. It's actions appear to be restricted to the nervous system. Ciliary neurotrophic factor(CNTF) has biological effects through the activation of a multi-subunit receptor complex, consisting of an extracelluar CNTF binding subunit(CNTFα) and two transmembrane signal transduction proteins: glycoprotein gp130 and LIF receptor. CNTF is considered as a potent survival factor of neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. CNTF is also a survival factor for neurons of the peripheral sensory sympathetic, and ciliary ganglia. It has been reported that CNTF could be an agent that has therapeutic potential and possibly induces differentiation of large multipolar ganglionic phenotype in a subset of progenitors.
• Product URL
• PDF URL
• Description
  The Recombinant CNTFR / CNTFR-alpha Protein (His tag) 100µg is a α- or alpha protein sometimes glycoprotein present in blood.
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CNTFR   CNTFR-alpha   Protein   His   tag   100µg  
• Gene symbol
  CNTFR, CNTFR-AS1
• Short name
  Recombinant CNTFR / CNTFR-alpha Protein (His tag) 100µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens ciliary neurotrophic factor receptor / ciliary neurotrophic factor receptor-a Protein (histidine detection labelled) 100µg
• Alternative technique
  rec
• Alternative to gene target
  ciliary neurotrophic factor receptor, CNTFR and IDBG-59992 and ENSG00000122756 and 1271, cytokine binding, Plasma membranes, Cntfr and IDBG-138110 and ENSMUSG00000028444 and 12804, BT.46623 and IDBG-635903 and ENSBTAG00000015361 and 539548

Gene info

• Identity
  HGNC:2170
• Gene
  CNTFR
• Long gene name
  ciliary neurotrophic factor receptor
• GenBank acession
  • M73238
• Locus
  9p13.3
• Discovery year
  1992-09-22
• Entrez gene record
  1271
• Pubmed identfication
  • 1648265
• Classification
  • Fibronectin type III domain containing
  • Immunoglobulin like domain containing
• VEGA ID
  OTTHUMG00000019821

Gene info

• Identity
  HGNC:48712
• Gene
  CNTFR-AS1
• Long gene name
  CNTFR antisense RNA 1
• GenBank acession
  • BC038740
  • BC042806
• Locus
  9p13.3
• Discovery year
  2013-06-07
• Entrez gene record
  415056
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000000441

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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