Recombinant Human Clusterin / Apolipoprotein J / Apo-J / CLU Protein (His tag)

• Catalog number
  PKSH031163-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  AAG4;APO-J;APOJ;CLI;CLU1;CLU2;KUB1;NA1/NA2;SGP-2;SGP2;SP-40;TRPM-2;TRPM2
• Activity
  NA
• Sequence
  Met 1-Glu 501
• Fusion tag
  C-His
• Accession
  NP_001822.2
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞92 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  51.5 kDa (24.5 + 27)
• AP Mol Mass
  37-39 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted protein which belongs to the clusterin family. Clusterin/Apolipoprotein J/Apo-J is an enigmatic glycoprotein with a nearly ubiquitous tissue distribution and an apparent involvement in biological processes ranging from mammary gland involution to neurodegeneration in Alzheimer's disease. Its major form, a heterodimer, is secreted and present in physiological fluids, but truncated forms targeted to the nucleus have also been identified. Clusterin/Apolipoprotein J/Apo-J is a widely distributed glycoprotein with a wide range of biologic properties. A prominent and defining feature of clusterin is its marked induction in such disease states as glomerulonephritis, cystic renal disease, renal tubular injury, neurodegenerative conditions, atherosclerosis, and myocardial infarction. Upregulation of clusterin mRNA and protein levels detected in diverse disease states and in in vitro systems have led to suggestions that it functions in membrane lipid recycling, in apoptotic cell death, and as a stress-induced secreted chaperone protein, amongst others.
• Technical data
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Clusterin   Apolipoprotein   Apo-J   CLU   Protein   His   tag  
• Gene symbol
  CLU
• Short name
  Recombinant Clusterin / Apolipoprotein J / Apo-J / CLU Protein (His tag)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens Clusterin / Apolipoprotein J / Apo-J / clusterin Protein (histidine detection labelled)
• Alternative technique
  rec
• Alternative to gene target
  clusterin, APO-J and APOJ and CLI and CLU1 and CLU2 and KUB1 and NA1/NA2 and SGP-2 and SGP2 and SP-40 and TRPM-2 and TRPM2, CLU and IDBG-14287 and ENSG00000120885 and 1191, misfolded protein binding, nuclei, Clu and IDBG-174736 and ENSMUSG00000022037 and 12759

Gene info

• Identity
  HGNC:2095
• Gene
  CLU
• Long gene name
  clusterin
• Synonyms gene
  • CLI
  • APOJ
• Synonyms gene name
  • clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)
• Synonyms
  • SGP-2
  • SP-40
  • TRPM-2
  • KUB1
  • CLU1
  • CLU2
• Synonyms name
  • complement lysis inhibitor
  • sulfated glycoprotein 2
  • testosterone-repressed prostate message 2
  • apolipoprotein J
• GenBank acession
  • M64722
• Locus
  8p21.1
• Discovery year
  1990-07-26
• Entrez gene record
  1191
• Pubmed identfication
  • 1585460
• RefSeq identity
  • NM_001831
• Classification
  • Complement system regulators and receptors
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000102114

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

Similar products