Recombinant Human CIB2 / KIP-2 Protein (His tag)

• Catalog number
  PKSH030805-20µg
• Price
  Please ask
• Size
  20µg

• Synonym
  DFNB48;KIP2;USH1J
• Activity
  NA
• Sequence
  Met 1-Ile 187
• Fusion tag
  N-His
• Accession
  O75838
• Expressed Host
  E. coli
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 75 % as determined by SDS-PAGE
• Endotoxin
  Please contact us for more information.
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  23.1 kDa
• AP Mol Mass
  27 kDa
• Formulation
  Lyophilized from sterile 50mM Tris, 20% glycerol, pH 8.0
• Background
  Calcium and integrin-binding protein 2 (CIB2) belongs to a protein family with four known members, CIB1 through CIB4, which are characterized by multiple calcium-binding EF-hand domains. Sensorineural hearing loss is genetically heterogeneous. The mutations in CIB2, which encodes a calcium- and integrin-binding protein, are associated with nonsyndromic deafness (DFNB48) and Usher syndrome type 1J (USH1J). Furthermore, in zebrafish and Drosophila melanogaster, CIB2 is essential for the function and proper development of hair cells and retinal photoreceptor cells. We also show that CIB2 is a new member of the vertebrate Usher interactome. Variants in CIB2 can underlie either Usher syndrome type I (USH1J) or nonsyndromic hearing impairment (NSHI) (DFNB48). CIB2 is widely expressed in various human and animal tissues, mainly in skeletal muscle, nervous tissue, inner ear, and retina. The CIB2 protein is responsible for maintaining Ca(2+) homeostasis in cells and interacting with integrins-transmembrane receptors essential for cell adhesion, migration, and activation of signaling pathways. Calcium signaling pathway is crucial for signal transduction in the inner ear, and integrins regulate hair cell differentiation and maturation of the stereocilia.
• Technical data
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CIB2   KIP-2   Protein   His   tag  
• Gene symbol
  CIB2, CDKN1C, CIB1, MIR7-2, MIR329-2, MIR512-2, MIR521-2, MIR1289-2, MIR509-2, KRTAP13-2
• Short name
  Recombinant CIB2 / KIP-2 Protein (His tag)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens calcium and integrin binding family member 2 / KIP-2 Protein (histidine detection labelled)
• Alternative technique
  rec
• Alternative to gene target
  calcium and integrin binding family member 2, DFNB48 and KIP2 and USH1J, CIB2 and IDBG-24446 and ENSG00000136425 and 10518, protein complex binding, Plasma membranes, Cib2 and IDBG-166743 and ENSMUSG00000037493 and 56506, CIB2 and IDBG-630943 and ENSBTAG00000010981 and 100337259

Gene info

• Identity
  HGNC:24579
• Gene
  CIB2
• Long gene name
  calcium and integrin binding family member 2
• Synonyms gene
  • DFNB48
  • USH1J
• Synonyms gene name
  • deafness, autosomal recessive 48
  • Usher syndrome 1J (autosomal recessive)
• Synonyms
  • KIP2
• Synonyms name
  • kinase interacting protein 2
• GenBank acession
  • BC047381
• Locus
  15q25.1
• Discovery year
  2004-04-20
• Entrez gene record
  10518
• Pubmed identfication
  • 9931475
  • 23023331
• RefSeq identity
  • NM_006383
• Classification
  • EF-hand domain containing
• VEGA ID
  OTTHUMG00000143731

Gene info

• Identity
  HGNC:1786
• Gene
  CDKN1C
• Long gene name
  cyclin dependent kinase inhibitor 1C
• Synonyms gene
  • BWCR
  • BWS
• Synonyms gene name
  • Beckwith-Wiedemann syndrome
  • cyclin-dependent kinase inhibitor 1C (p57, Kip2)
• Synonyms
  • P57
  • KIP2
• GenBank acession
  • D64137
• Locus
  11p15.4
• Discovery year
  1995-09-14
• Entrez gene record
  1028
• Pubmed identfication
  • 7729684
• RefSeq identity
  • NM_000076
• VEGA ID
  OTTHUMG00000010040
• Locus Specific Databases
  • LRG_533

Gene info

• Identity
  HGNC:16920
• Gene
  CIB1
• Long gene name
  calcium and integrin binding 1
• Synonyms
  • SIP2-28
  • CIB
  • KIP
• Synonyms name
  • calmyrin
• GenBank acession
  • U82226
• Locus
  15q26.1
• Discovery year
  2002-05-08
• Entrez gene record
  10519
• Pubmed identfication
  • 9030514
  • 10826701
• Classification
  • EF-hand domain containing
• VEGA ID
  OTTHUMG00000149808

Gene info

• Identity
  HGNC:31639
• Gene
  MIR7-2
• Long gene name
  microRNA 7-2
• Synonyms gene
  • MIRN7-2
• Synonyms
  • hsa-mir-7-2
• Locus
  15q26.1
• Discovery year
  2004-04-23
• Entrez gene record
  407044
• RefSeq identity
  • NR_029606
• Classification
  • MicroRNA MIR7 family

Gene info

• Identity
  HGNC:32051
• Gene
  MIR329-2
• Long gene name
  microRNA 329-2
• Synonyms gene
  • MIRN329-2
• Synonyms
  • hsa-mir-329-2
• Locus
  14q32.31
• Discovery year
  2005-07-11
• Entrez gene record
  574409
• RefSeq identity
  • NR_029968
• Classification
  • MicroRNA MIR329 family

Gene info

• Identity
  HGNC:32091
• Gene
  MIR512-2
• Long gene name
  microRNA 512-2
• Synonyms gene
  • MIRN512-2
• Synonyms
  • hsa-mir-512-2
• Locus
  19q13.42
• Discovery year
  2005-07-15
• Entrez gene record
  574459
• RefSeq identity
  • NR_030181
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:32113
• Gene
  MIR521-2
• Long gene name
  microRNA 521-2
• Synonyms gene
  • MIRN521-2
• Synonyms
  • hsa-mir-521-2
• Locus
  19q13.42
• Discovery year
  2005-07-15
• Entrez gene record
  574481
• RefSeq identity
  • NR_030203
• Classification
  • MicroRNA MIR515 family

Gene info

• Identity
  HGNC:35282
• Gene
  MIR1289-2
• Long gene name
  microRNA 1289-2
• Synonyms gene
  • MIRN1289-2
• Synonyms
  • hsa-mir-1289-2
• Locus
  5q31.1
• Discovery year
  2008-11-03
• Entrez gene record
  100302134
• RefSeq identity
  • NR_031621
• Classification
  • MicroRNA MIR1289 family

Gene info

• Identity
  HGNC:33641
• Gene
  MIR509-2
• Long gene name
  microRNA 509-2
• Synonyms gene
  • MIRN509-2
• Synonyms
  • hsa-mir-509-2
• Locus
  Xq27.3
• Discovery year
  2007-10-24
• Entrez gene record
  100126301
• RefSeq identity
  • NR_030586
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:18923
• Gene
  KRTAP13-2
• Long gene name
  keratin associated protein 13-2
• Synonyms
  • KAP13-2
• GenBank acession
  • AP001708
• Locus
  21q22.11
• Discovery year
  2003-02-21
• Entrez gene record
  337959
• Pubmed identfication
  • 12359730
• Classification
  • Keratin associated proteins
• VEGA ID
  OTTHUMG00000057793

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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