Recombinant Human CD112 / Nectin-2 / PVRL2 Protein
-
Catalog number
PKSH031939-50µg
-
Price
Please ask
-
Size
50µg
-
-
Synonym
CD112;HVEB;Nectin-2;PRR2;PVRR2
-
Activity
Measured by its binding ability in a functional ELISA.Immobilized human CD112 at 10 μg/ml (100 μl/well) can bind human DNAM1-Fch with a linear range of 1.25-10 μg/ml.
-
Sequence
Met 1-Leu 360
-
Fusion tag
NA
-
Accession
NP_002847.1
-
Expressed Host
HEK293 Cells
-
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
-
Purity
＞95 % as determined by SDS-PAGE and SEC-HPLC Analysis.
-
Endotoxin
＜1.0 EU per µg as determined by the LAL method
-
Stability and Storage
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Mol Mass
36.2 kDa
-
AP Mol Mass
48 kDa
-
Formulation
Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5
-
Background
Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.
-
-
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
-
Source
Recombinants or rec. proteins
-
Group
recombinants
-
Gene target
-
Gene symbol
NECTIN2
-
Short name
Recombinant CD112 / Nectin-2 / PVRL2 Protein
-
Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
-
Species
Human, Humans
-
Alternative name
Rec. H. sapiens CD112 / Nectin-2 / poliovirus receptor-related 2 (herpesvirus entry mediator B) Protein
-
Alternative technique
rec
-
Alternative to gene target
poliovirus receptor-related 2 (herpesvirus entry mediator B), CD112 and HVEB and PRR2 and PVRR2, PVRL2 and IDBG-56684 and ENSG00000130202 and 5819, cell adhesion molecule binding, Cell surfaces, Pvrl2 and IDBG-152351 and ENSMUSG00000062300 and 19294, PVRL2 and IDBG-639286 and ENSBTAG00000015318 and 505580
-
Gene info
MeSH Data
-
Name
-
Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
-
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
-
Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
Similar products
