Recombinant Human BMPR1B / ALK-6 (149-502) Protein (His & GST tag)

• Catalog number
  PKSH030412-20µg
• Price
  Please ask
• Size
  20µg

• Synonym
  ALK-6;ALK6;CDw293
• Activity
  NA
• Sequence
  Arg 149-Leu 502
• Fusion tag
  N-His & GST
• Accession
  NP_001194.1
• Expressed Host
  Baculovirus-Insect Cells
• Shipping
  Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.Shipment made at ambient temperature may seriously affect the activity of the ordered products.
• Purity
  ＞90 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  68.3 kDa
• AP Mol Mass
  55 kDa
• Formulation
  Supplied as sterile 50mM Tris, 100mM NaCl, pH 8.5, 20% gly, 0.3mM DTT
• Background
  BMPR1B(bone morphogenetic protein receptor, type IB), also known as ALK6, is a a member of the bone morphogenetic protein (BMP) receptor family. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMPR1B is the major transducer of signals in precartilaginous condensations as demonstrated in experiments using constitutively active BMPR1B receptors. BMPR1B is a more effective trasducer of GDF5 than BMPR1A. Unlike BMPR1A null mice, which die at an early embryonic stage, BMPR1B null mice are viable.
• Technical data
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  BMPR1B   ALK-6   149-502   Protein   His   GST   tag  
• Gene symbol
  BMPR1B, BMPR1B-DT, MGST3, ALK, ENPP7, MIR149, MIR502, CHMP3, TGFBR1, BMPR2
• Short name
  Recombinant BMPR1B / ALK-6 (149-502) Protein (His & GST tag)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens bone morphogenetic protein receptor, classification IB / anaplastic lymphoma receptor tyrosine kinase-6 (149-502) Protein (histidine & GST detection labelled)
• Alternative technique
  rec
• Alternative to gene target
  bone morphogenetic protein receptor, type IB, ALK-6 and ALK6 and CDw293, BMPR1B and IDBG-30667 and ENSG00000138696 and 658, transforming growth factor beta receptor activity, Plasma membranes, Bmpr1b and IDBG-196928 and ENSMUSG00000052430 and 12167, BMPR1B and IDBG-641011 and ENSBTAG00000002081 and 407128

Gene info

• Identity
  HGNC:1077
• Gene
  BMPR1B
• Long gene name
  bone morphogenetic protein receptor type 1B
• Synonyms gene name
  • bone morphogenetic protein receptor, type IB
• Synonyms
  • ALK6
  • CDw293
• GenBank acession
  • D89675
• Locus
  4q22.3
• Discovery year
  1997-03-19
• Entrez gene record
  658
• Pubmed identfication
  • 8140412
  • 9730621
• RefSeq identity
  • NM_001203
• Classification
  • CD molecules
  • Type 1 receptor serine/threonine kinases
• VEGA ID
  OTTHUMG00000130991

Gene info

• Identity
  HGNC:50864
• Gene
  BMPR1B-DT
• Long gene name
  BMPR1B divergent transcript
• Synonyms gene
  • BMPR1B-AS1
• Synonyms gene name
  • BMPR1B antisense RNA 1 (head to head)
• Synonyms
  • TCONS_00007797
• Locus
  4q22.3
• Discovery year
  2014-07-14
• Entrez gene record
  100507012
• Classification
  • Divergent transcripts
• VEGA ID
  OTTHUMG00000161193

Gene info

• Identity
  HGNC:7064
• Gene
  MGST3
• Long gene name
  microsomal glutathione S-transferase 3
• Synonyms
  • GST-III
• Synonyms name
  • microsomal glutathione S-transferase III
  • microsomal GST-3
  • microsomal GST-III
• GenBank acession
  • AF026977
• Locus
  1q24.1
• Discovery year
  1997-10-16
• Entrez gene record
  4259
• Pubmed identfication
  • 9278457
• RefSeq identity
  • NM_004528
• Classification
  • Microsomal glutathione S-transferases
• VEGA ID
  OTTHUMG00000034627

Gene info

• Identity
  HGNC:427
• Gene
  ALK
• Long gene name
  ALK receptor tyrosine kinase
• Synonyms gene name
  • anaplastic lymphoma kinase (Ki-1)
  • anaplastic lymphoma receptor tyrosine kinase
• Synonyms
  • CD246
  • ALK1
• GenBank acession
  • D45915
• Locus
  2p23.2-p23.1
• Discovery year
  1993-08-24
• Entrez gene record
  238
• Pubmed identfication
  • 8122112
• RefSeq identity
  • NM_004304
• Classification
  • Receptor tyrosine kinases
  • CD molecules
• VEGA ID
  OTTHUMG00000152034
• Locus Specific Databases
  • LRG_488

Gene info

• Identity
  HGNC:23764
• Gene
  ENPP7
• Long gene name
  ectonucleotide pyrophosphatase/phosphodiesterase 7
• Synonyms
  • alk-SMase
  • NPP7
• Synonyms name
  • alkaline sphingomyelinase
• GenBank acession
  • AY230663
• Locus
  17q25.3
• Discovery year
  2004-04-29
• Entrez gene record
  339221
• Pubmed identfication
  • 12885774
• RefSeq identity
  • NM_178543
• Classification
  • Ectonucleotide pyrophosphatase/phosphodiesterase family
• VEGA ID
  OTTHUMG00000177462

Gene info

• Identity
  HGNC:31536
• Gene
  MIR149
• Long gene name
  microRNA 149
• Synonyms gene
  • MIRN149
• Synonyms
  • hsa-mir-149
• Locus
  2q37.3
• Discovery year
  2004-04-23
• Entrez gene record
  406941
• Pubmed identfication
  • 23298478
• RefSeq identity
  • NR_029702
• Classification
  • MicroRNAs

Gene info

• Identity
  HGNC:32136
• Gene
  MIR502
• Long gene name
  microRNA 502
• Synonyms gene
  • MIRN502
• Synonyms
  • hsa-mir-502
• Locus
  Xp11.23
• Discovery year
  2005-07-15
• Entrez gene record
  574504
• RefSeq identity
  • NR_030226
• Classification
  • MicroRNA MIR500 family

Gene info

• Identity
  HGNC:29865
• Gene
  CHMP3
• Long gene name
  charged multivesicular body protein 3
• Synonyms gene
  • VPS24
• Synonyms gene name
  • vacuolar protein sorting 24 (yeast)
  • vacuolar protein sorting 24 homolog (S. cerevisiae)
• Synonyms
  • NEDF
  • CGI-149
• GenBank acession
  • AF219226
• Locus
  2p11.2
• Discovery year
  2004-03-11
• Entrez gene record
  51652
• Pubmed identfication
  • 11549700
  • 12878588
• RefSeq identity
  • NM_016079
• Classification
  • ESCRT-III
  • Charged multivesicular body proteins
• VEGA ID
  OTTHUMG00000153189

Gene info

• Identity
  HGNC:11772
• Gene
  TGFBR1
• Long gene name
  transforming growth factor beta receptor 1
• Synonyms gene
  • MSSE
  • ESS1
• Synonyms gene name
  • multiple self-healing squamous epithelioma
  • transforming growth factor beta receptor I
• Synonyms
  • ALK-5
  • ACVRLK4
  • ALK5
  • TBRI
  • TBR-i
• Synonyms name
  • activin A receptor type II-like kinase, 53kDa
• Locus
  9q22.33
• Discovery year
  1993-09-30
• Entrez gene record
  7046
• Pubmed identfication
  • 1319842
  • 8530052
  • 21358634
• Classification
  • Type 1 receptor serine/threonine kinases
• VEGA ID
  OTTHUMG00000020353
• Locus Specific Databases
  • LOVD - Center for Medical Genetics, Ghent, Belgium

Gene info

• Identity
  HGNC:1078
• Gene
  BMPR2
• Long gene name
  bone morphogenetic protein receptor type 2
• Synonyms gene
  • PPH1
• Synonyms gene name
  • primary pulmonary hypertension 1
  • bone morphogenetic protein receptor, type II (serine/threonine kinase)
  • bone morphogenetic protein receptor type II
• Synonyms
  • BRK-3
  • T-ALK
  • BMPR3
  • BMPR-II
• GenBank acession
  • Z48923
• Locus
  2q33.1-q33.2
• Discovery year
  1997-03-19
• Entrez gene record
  659
• Pubmed identfication
  • 7791754
• RefSeq identity
  • NM_001204
• Classification
  • Type 2 receptor serine/threonine kinases
• VEGA ID
  OTTHUMG00000133617
• Locus Specific Databases
  • LRG_712

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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