Recombinant Human CD80 / B7-1 Protein (His tag)
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Catalog number
PKSH031477-100µg
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Price
Please ask
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Size
100µg
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Synonym
B7;B7-1;B7.1;BB1;CD28LG;CD28LG1;LAB7
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Activity
Measured by its ability to bind recombinant human CD28 in a functional ELISA.
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Sequence
Met 1-Asn 242
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Fusion tag
C-His
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Accession
NP_005182.1
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Expressed Host
HEK293 Cells
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Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity
＞95 % as determined by SDS-PAGE
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Endotoxin
＜1.0 EU per µg as determined by the LAL method
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Stability and Storage
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass
25.4 kDa
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AP Mol Mass
45-48 kDa
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Formulation
Lyophilized from sterile PBS, pH 7.4
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Background
The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.Immune CheckpointImmune Checkpoint Detection: Antibodies Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: IHC Antibodies Immune Checkpoint Detection: FCM Antibodies Immune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint Targets Co-inhibitory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy
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Conjugation
histidine
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
CD80, HHLA2, RNY4P2, LRRC23, PCDHGB7, NCR3LG1, CD274, CD86, TLX1NB, CD276
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Short name
Recombinant CD80 / B7-1 Protein (His tag)
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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Label
His
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Species
Human, Humans
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Alternative name
Rec. H. sapiens CD80 molecule / B7-1 Protein (histidine detection labelled)
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Alternative technique
rec
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Alternative to gene target
CD80 molecule, B7 and B7-1 and B7.1 and BB1 and CD28LG and CD28LG1 and LAB7, CD80 and IDBG-51287 and ENSG00000121594 and 941, coreceptor activity, Cell surfaces, Cd80 and IDBG-160288 and ENSMUSG00000075122 and 12519, BT.27986 and IDBG-632750 and ENSBTAG00000018059 and 407131
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Gene info
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Identity
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Gene
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Long gene name
CD80 molecule
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Synonyms gene
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Synonyms gene name
- CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)
- CD80 molecule
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Synonyms
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Synonyms name
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Locus
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Discovery year
1993-12-14
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- B7 family
- CD molecules
- C2-set domain containing
- V-set domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
HERV-H LTR-associating 2
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Synonyms
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GenBank acession
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Locus
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Discovery year
1999-09-07
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C1-set domain containing
- V-set domain containing
- B7 family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
RNY4 pseudogene 2
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Synonyms gene name
- RNA, Y4 small cytoplasmic (associated with Ro protein) pseudogene 2
- RNA, Ro-associated Y4 pseudogene 2
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Synonyms
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GenBank acession
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Locus
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Discovery year
1993-08-25
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Entrez gene record
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RefSeq identity
Gene info
Gene info
Gene info
Gene info
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Identity
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Gene
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Long gene name
CD274 molecule
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Synonyms gene
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Synonyms gene name
- programmed cell death 1 ligand 1
- CD274 antigen
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
2003-11-13
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Receptor ligands
- C2-set domain containing
- V-set domain containing
- B7 family
- CD molecules
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
CD86 molecule
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Synonyms gene
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Synonyms gene name
- CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
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Synonyms
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Synonyms name
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Locus
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Discovery year
1994-12-07
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- B7 family
- CD molecules
- V-set domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
TLX1 neighbor
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
2009-08-14
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Long non-coding RNAs with non-systematic symbols
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
CD276 molecule
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Synonyms gene name
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Synonyms
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GenBank acession
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Locus
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Discovery year
2005-03-04
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C2-set domain containing
- V-set domain containing
- B7 family
- CD molecules
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VEGA ID
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