RCAN2 Isoform 2 Recombinant Protein

• Catalog number
  95-114
• Price
  Please ask
• Size
  0.05 mg

• About recombinant protein
  Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle (1,2). Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin’s activity (3). Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3 (3). RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome (4).
• Other name of the recombinant
  RCAN2 Antibody: Csp2, MCIP2, ZAKI-4, Dscr1l1, Zaki4, Calcipressin-2, Calcineurin inhibitory protein ZAKI-4
• Recombinant in
  E. coli
• His tag on the recombinant protein
  Fusion Partner: C-terminal His-tag
• SEQUENCE
  aa 2 - 197
• Activity
  not available
• Use of recmbinant
  This recombinant protein can be used for WB, ELISA, MS and neutralization assays.
• Protein is used in
  E, WB, MS
• Suspention medium
  100mM sodium phosphate, 10mM Tris, 500mM NaCl, 25 mM imidazole, 2mM MgCl2, 10% gycerol
• Keep at
  Store in working aliquots at -70˚C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
• Rec PROTEIN GI
  38328420
• Accession nr
  AAH62141
• KDa of reombinant
  26 kDa (Calculated)
• Pureity
  ~95%
• About
  Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
• Protein s origin
  Mouse
• Vial
  Liquid
• NCBI ID
  53901
• Gene name
  regulator of calcineurin 2
• Source
  Mus musculus
• Uniprot
  Q9JHG2
• Pictures of recombinant
• Rec pdf
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  RCAN2   Isoform   Protein  
• Gene symbol
  Rcan2
• Short name
  RCAN2 Isoform 2 Recombinant Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Alternative name
  RCAN2 Isoform 2 Rec. Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:55661
• Gene
  RCAN2-DT
• Long gene name
  RCAN2 divergent transcript
• Locus
  6p12.3
• Discovery year
  2021-06-30
• Entrez gene record
  101926898
• RefSeq identity
  • NR_125837
• Classification
  • Divergent transcripts

Gene info

• Identity
  HGNC:3041
• Gene
  RCAN2
• Long gene name
  regulator of calcineurin 2
• Synonyms gene
  • DSCR1L1
• Synonyms gene name
  • Down syndrome critical region gene 1-like 1
• Synonyms
  • ZAKI-4
• GenBank acession
  • D83407
• Locus
  6p12.3
• Discovery year
  1999-08-20
• Entrez gene record
  10231
• Pubmed identfication
  • 8662924
• VEGA ID
  OTTHUMG00000014782

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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