Rb/P105 RB (Thr821) Antibody, ALEXA FLUOR 488

  • Catalog number
    bs-3452R-A488
  • Price
    Please ask
  • Size
    100ul
  • Long name
    Rb/P105 RB (Thr821) Polyclonal Antibody, ALEXA FLUOR 488 Conjugated
  • Also known as
    Anti-Rb/P105 RB Thr821 PAb ALEXA FLUOR 488
  • Category
    Conjugated Primary Antibodies
  • Conjugated with
    ALEXA FLUOR® 488
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Target Antigen
    Rb/P105 RB Thr821
  • Specificity
    This is a highly specific antibody against Rb/P105 RB Thr821.
  • Modification
    Phosphorylation
  • Modification Site
    Thr821
  • Clonality
    Polyclonal
  • Clone
    Polyclonal antibody
  • Concentration
    1ug per 1ul
  • Source
    KLH conjugated synthetic phosphopeptide derived from human Retinoblastoma associated protein around the phosphorylation site of Thr821
  • Gene ID Number
    5925
  • Tested applications
    IF(IHC-P)
  • Recommended dilutions
    IF(IHC-P)(1:50-200)
  • Crossreactivity
    Human, Mouse, Rat
  • Cross reactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Background of the antigen
    Rb is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F1, PU1, ATF2, UBF, Elf1 and cAbl. This ability of Rb to alter transcription is regulated by phosphorylation catalyzed by the cyclin dependent protein kinases (cdks). Rb is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus 16E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the Rb gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
  • Purification
    Purified by Protein A.
  • Storage conditions
    Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
  • Excitation emission
    499nm/519nm
  • Synonyms
    OSRC; P105 RB; P105RB; PP105; PP110; pRb; RB 1; RB1; RB1 protein; Retinoblastoma 1 including osteosarcoma; Retinoblastoma 1; Retinoblastoma associated protein; Retinoblastoma related osteosarcoma; Retinoblastoma susceptibility gene; Including osteosarcoma; RB_HUMAN.
  • Properties
    For facs or microscopy Alexa 1 conjugate. Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-Rb/P105 RB Thr821 has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • Conjugation
    Alexa Fluor
  • French translation
    anticorps
  • Gene target
    Rb/P105   Thr821  
  • Gene symbol
    NFKB2, SCYL1, NFKB1
  • Short name
    Anti-Rb/P105 RB Thr821
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Isotype
    Immunoglobulin G (IgG)
  • Label
    ALEXA FLUOR 488
  • Alternative name
    Rb/P105 RB (Thr821) Polyclonal Antibody, ALEXA FLUOR 488
  • Alternative technique
    antibodies
Gene info
  • Identity
  • Gene
  • Long gene name
    nuclear factor kappa B subunit 2
  • Synonyms gene name
    • nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1991-11-14
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • IPT domain containing
    • NF-kappa B complex subunits
    • Ankyrin repeat domain containing
  • VEGA ID
  • Locus Specific Databases
Gene info
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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