RASGAP Antibody / RASA1

  • Catalog number
    R32007
  • Price
    Please ask
  • Size
    0.1mg
  • Category
    Antibody
  • Concentration
    0.5mg/ml if reconstituted with 0.2ml sterile DI water
  • Form
    Antigen affinity purified
  • Conjugation
    Unconjugated
  • Clone
    Polyclonal antibody
  • Recognised antigen
    RASGAP / RASA1
  • Host animal
    Rabbit (Oryctolagus cuniculus)
  • Clonality
    Polyclonal (rabbit origin)
  • Species reactivity
    Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
  • Tested applications
    WB
  • Recommended dilutions
    Western blot: 0.1-0.5ug/ml
  • Notes
    Optimal dilution of the RASGAP antibody should be determined by the researcher.
  • Intented use
    This RASGAP antibodyis to be used only for research purposes and not for diagnostics..
  • Uniprot
    P20936
  • Purity
    Antigen affinity
  • Description
    RASA1, also known as RAS p21 protein activator 1 or RASGAP, is a 120-kDa cytosolic human protein. The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.
  • Immunogen
    Amino acids AQQHVLKKLLAITELLQQKQNQYTKTNDVR of human RASA1 were used as the immunogen for the RASGAP antibody.
  • Storage
    After reconstitution, the RASGAP antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
  • Properties
    If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
    RASGAP   RASA1  
  • Gene symbol
    RASA1
  • Short name
    Anti-RASGAP / RASA1
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Isotype
    Rabbit IgG
  • Alternative name
    Antibodies to RASGAP / RASA1
  • Alternative technique
    antibodies
  • Alternative to gene target
    RAS p21 protein activator (GTPase activating protein) 1, CM-AVM and CMAVM and GAP and p120GAP and p120RASGAP and PKWS and RASA and RASGAP, RASA1 and IDBG-32785 and ENSG00000145715 and 5921, GTPase binding, Plasma membranes, Rasa1 and IDBG-170464 and ENSMUSG00000021549 and 218397, BT.102247 and IDBG-646529 and ENSBTAG00000009565 and 282032
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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