RALA Antibody

• Catalog number
  R31943
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  RALA
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.1-0.5ug/ml
• Notes
  Optimal dilution of the RALA antibody should be determined by the researcher.
• Intented use
  This RALA antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P11233
• Purity
  Antigen affinity
• Description
  Ras-related protein Ral-A (RalA) is a protein that in humans is encoded by the RALA gene on chromosome 7. This protein is one of two isoforms of the Ral protein, the other being RalB, and part of the Ras GTPase family. As a Ras GTPase, RalA functions as a molecular switch that becomes active when bound to GTP and inactive when bound to GDP. It can be activated by RalGEFs and, in turn, activate effectors in signal transduction pathways leading to biological outcomes. Additionally, Ral proteins have been associated with the progression of several cancers, including bladder cancer and prostate cancer. While the above functions appear to be shared between the two Ral isoforms, their differential subcellular localizations result in their differing involvement in certain biological processes. In particular, RalA is more involved in anchorage-independent cell growth, vesicle trafficking, and cytoskeletal organization. Moreover, RalA specifically interacts with Exo84 and Sec5 to regulate transport of membrane proteins in polarized epithelial cells and GLUT4 to the plasma membrane, as well as mitochondrial fission for cell division.
• Immunogen
  Amino acids DKVFFDLMREIRARKMEDSKEKNGKKKRKSLAKRIRERC of human RALA were used as the immunogen for the RALA antibody.
• Storage
  After reconstitution, the RALA antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  RALA  
• Gene symbol
  RALA
• Short name
  Anti-RALA
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to RALA
• Alternative technique
  antibodies
• Alternative to gene target
  v-ral simian leukemia viral oncogene homolog A (ras related), RAL, RALA and IDBG-13210 and ENSG00000006451 and 5898, Edg-2 lysophosphatidic acid receptor binding, Cell surfaces, Rala and IDBG-132005 and ENSMUSG00000008859 and 56044, RALA and IDBG-634566 and ENSBTAG00000006661 and 538477

Gene info

• Identity
  HGNC:9839
• Gene
  RALA
• Long gene name
  RAS like proto-oncogene A
• Synonyms gene
  • RAL
• Synonyms gene name
  • v-ral simian leukemia viral oncogene homolog A (ras related)
• Synonyms name
  • RAS-like protein A
  • Ras-related protein Ral-A
  • Ras family small GTP binding protein RALA
  • ras related GTP binding protein A
• Locus
  7p14.1
• Discovery year
  2001-06-22
• Entrez gene record
  5898
• Pubmed identfication
  • 3292391
• RefSeq identity
  • NM_005402
• Classification
  • RAS type GTPase family
• VEGA ID
  OTTHUMG00000128775

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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