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RAGE Antibody, PE Conjugated

RAGE Antibody, PE Conjugated is available 1 time from Bioss primary conjugated antibodies labs

bs-0177R-PE | RAGE Antibody, PE Conjugated size: 0.1ml | 415.29 USD

Properties If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation anticorps
1. Gene info
Identity 320
Gene AGER
Long gene name advanced glycosylation end-product specific receptor
Synonyms
  • RAGE
  • SCARJ1
Synonyms name
  • receptor for advanced glycation end-products
GenBank acession
  • M91211
Locus 6p21.32
Discovery year 1994-10-17
Entrez gene record 177
Pubmed identfication
  • 7713518
RefSeq identity
  • NM_001136
Classification
  • Scavenger receptors
  • C2-set domain containing
  • Immunoglobulin like domain containing
Havana BLAST/BLAT OTTHUMG00000031120
MeSH Data
Name Blotting, Western
Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
Long name RAGE Polyclonal Antibody, PE Conjugated
Category Conjugated Primary Antibodies
Conjugation PE
Host Organism Rabbit (Oryctolagus cuniculus)
Target Antigen RAGE
Specificity This is a highly specific antibody against RAGE.
Modification Unmodified
Modification site None
Clonality Polyclonal
Clone Polyclonal antibody
Concentration 1ug per 1ul
Immunogen_range 140-190/402
Subcellular location Extracellular
Source KLH conjugated synthetic peptide derived from rat AGER
Gene ID number 81722
Swiss Prot Q63495
Tested applications FCM
Recommended dilutions FCM(1:20-100)
Crossreactivity Rat
Crossreactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Antigen background Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S1A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides (By similarity). Interaction with S1B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.
Purification method This antibody was purified via Protein A.
Storage conditions Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
Excitation Emission 480,565nm/578nm
Synonyms RAGE; Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products; Ager
Gene targetRAGE Conjugated
Short name RAGE Antibody, PE Conjugated
Technique Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
Label PE
Alternative name RAGE (Antibody to), peroxidase coupled
Alternative technique antibodies
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