RAD50 Antibody

• Catalog number
  bs-11230R
• Price
  Please ask
• Size
  0.1ml

• Long name
  RAD50 Primary Polyclonal Antibody
• Also known as
  RAD50 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  RAD50
• Specificity
  This is a highly specific antibody against RAD50.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  817-872/1312
• Subcellular location
  Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human RAD50
• Gene ID number
  10111
• Swiss Prot
  Q92878
• Tested Applications
  WB
• Recommended dilutions
  WB(1:100-1000)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point (PubMed:11741547, PubMed:9590181, PubMed:9705271, PubMed:9651580). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888).
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  DNA repair protein RAD50; RAD50; hRAD50
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  RAD50  
• Gene symbol
  RAD50
• Short name
  Anti-RAD50
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  RAD50 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:9816
• Gene
  RAD50
• Long gene name
  RAD50 double strand break repair protein
• Synonyms gene name
  • RAD50 (S. cerevisiae) homolog
  • RAD50 homolog (S. cerevisiae)
  • RAD50 homolog, double strand break repair protein
• Synonyms
  • hRad50
  • RAD50-2
• GenBank acession
  • Z75311
• Locus
  5q31.1
• Discovery year
  1999-07-23
• Entrez gene record
  10111
• Pubmed identfication
  • 8756642
  • 9705271
• RefSeq identity
  • NM_005732
• Classification
  • BRCA1 C complex
  • MRN complex
• VEGA ID
  OTTHUMG00000059613
• Locus Specific Databases
  • LRG_312

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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