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Availability
Please contact us to check the availability
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Immunogen
Recombinant fragment of human progesterone receptor aa 412-526
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Specificity
Human progesterone receptor protein
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Species reactivity
Human
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Product presentation
Antibody solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide**.
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Product category
Primary Antibody
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Antibody s raised in
Rabbit
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Antibody s isotype
IgG
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Antibody s clone
ZR4
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Product is supplied as
liquid concentrate
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Recommended concentration for use
1:40-1:80
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Protein concentration
N/A
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Positive control
Lobular and tubular mamma carcinoma
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Pretreatment
Pre-treatment using high temperature unmasking methods e.g. with citrate buffer (Art. No. DE000) or TRIS/EDTA (Art.-No. DE006)
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Tested applications
IHC(P)
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Recommended secondary reagent
VECTASTAIN Elite ABC Rabbit IgG (PK-6101) or ImmPRESS Rabbit IgG (MP-7401) or other polymer kits detecting rabbit IgG.
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Storage method
Store at 2-8°C
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UniProt number
Go to UniProt/SwissProt
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Litterature
1. Stewart J., King R., Hayward J., et al. (1982) Oestrogen and progesterone receptors: correlation of response rates, sites and timing of analysis. Breast Cancer Research and Treatment 2; 243-252. 2.. Clark G.M., McGuire W.L., Hubay C.A. et al. (1983) Progesterone receptors as a prognostic factor in stage II breast cancer. The New England J. Med. 309(22); 1343-1347. 3. Giri D.D., Goepel J.R., Rogers K., et al. (1988) Immunohistological demonstration of progesterone receptor in breast carcinomas: correlation with radioligand binding assays and oestrogen receptor immunohistology. J. Clin. Pathol. 41; 444-447. 4. Kell D.L., et al. (1993) Immunohistochemical analysis of breast carcinoma estrogen and progesterone receptors in paraffin-embedded tissue: Correlation of clones ER 1D5 and 1A6 with a cytosol-based hormone receptor assay. Appl. Immunohistochem. 1(4); 275 ff.
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Tips
*Gentaur's antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals. ** The preservative sodium azide is known to be poisonous and potentially hazardous to health. It should be handled only by trained staff. Despite of the product's low azide concentration it must be handled with care. Dispose according to regional rules!
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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About
Immunoglobulin gamma, IgG, mouse monoclonal H&L chain clones or rabbit, goat polyclonal antibodies have 4 parts. There are 2 heavy chains, 2 light chains. The IgG antibody has 2 antigen binding sites. They represent 70% or more of serum antibodies. This antibody can be antigen purified or protein A or G purified. For storage sodium azide is added or you can call us to request azide free antibody preparations. These will need colder storage temperatures. Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes. Rabbits are used for polyclonal antibody production by bio logo. Rabbit antibodies are very stable and can be stored for several days at room temperature. bio logo adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin name
Oryctolagus cuniculus
