Rabbit Monoclonal IgG Anti-C-erbB-2 Onkoprotein (HER-2/neu) [ZR5]
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Catalog number
CE110-G
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Price
Please ask
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Size
5 ml
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Availability
Please contact us to check the availability
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Immunogen
Recombinant protein according to the extracellular domain of the c-erbB2 molecule
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Specificity
C-erbB-2 oncoprotein
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Species reactivity
Human
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Product presentation
Cell culture medium with BSA and Sodium Azide as preservative
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Product category
Primary Antibody
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Antibody s raised in
Rabbit
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Antibody s isotype
IgG
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Antibody s clone
ZR5
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Product is supplied as
RTU
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Recommended concentration for use
neat
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Protein concentration
N/A
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Positive control
Mamma carcinoma
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Pretreatment
Improvement of staining with Unmasking Fluid E (Art. No. DE006) or Unmasking Fluid T (Art. No. DE005)
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Tested applications
IHC(C, P)
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Recommended secondary reagent
We recommend the use of Gentaur's Universal Staining System DAB (Art. No. DA005) or AEC (Art.-No. AE005), if higher sensitivity is required VECTASTAIN Elite ABC (Art. No. PK-6102) or ABC AP (Art. No. AK-5002) systems are applicable.
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Storage method
Store at 2-8°C
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UniProt number
Go to UniProt/SwissProt
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Litterature
1. Van de Vijver M. J., et al. (1988) Immunohistochemical detection of the neu-protein in tissue sections of human breast tumours with amplified neu-DNA. Oncogene 2; 175-178. 2. Flack V.G. et al., et al. (1989) C-erb B-2 oncogene product staining in gastric adenocarcinoma. An immunohistochemical study. J. Pathol. 159; 107-111. 3. May E., Mouriesse H., May-Levin F., Quian J.F., May P., and Delarue J.C. (1990) Human breast cancer: Identification of populations with a high risk of early relapse in relation to both oestrogen receptor status and c-erbB-2 overexpression. Br. J. Cancer 62; 430-435. 4. Soomro S., Shousha S., Taylor P., Shephard H.M., Feldmann M. (1991) C-erbB-2 expression in different histological types of invasive breast carcinoma. J. Clin. Pathol. 44; 211-214. 5. Xia W ; Lau YK ; Zhang HZ ; Liu AR ; Li L ; Kiyokawa N ; Clayman GL ; Katz RL ; Hung MC TI (1997)- Strong correlation between c-erbB-2 overexpression and overall survival of patients with oral squamous cell carcinoma. - Clin Cancer Res 3(1):3-9.
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Tips
*Gentaur's antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals. ** The preservative sodium azide is known to be poisonous and potentially hazardous to health. It should be handled only by trained staff. Despite of the product's low azide concentration it must be handled with care. Dispose according to regional rules!
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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About
Immunoglobulin gamma, IgG, mouse monoclonal H&L chain clones or rabbit, goat polyclonal antibodies have 4 parts. There are 2 heavy chains, 2 light chains. The IgG antibody has 2 antigen binding sites. They represent 70% or more of serum antibodies. This antibody can be antigen purified or protein A or G purified. For storage sodium azide is added or you can call us to request azide free antibody preparations. These will need colder storage temperatures. Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes. Rabbits are used for polyclonal antibody production by bio logo. Rabbit antibodies are very stable and can be stored for several days at room temperature. bio logo adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin name
Oryctolagus cuniculus
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Gene target
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Gene symbol
ERBB2, MIR7-2, MIR329-2, MIR512-2, MIR521-2, MIR1289-2, MIR509-2, KRTAP13-2, RNU6-2, SNORD116-2
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Short name
Bioprime
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Technique
Rabbit, anti-, anti, IgG, antibody to, antibodies, IgGs, Monoclonals or monoclonal antibodies
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Host
Rabbit, Rabbits
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Isotype
IgG, IgG
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Alternative name
C-erbB-2 Onkoprotein, HER-2/neu
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Alternative technique
rabbit-anti, antibodies, immunoglobulins
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Gene info
Gene info
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Identity
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Gene
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Long gene name
microRNA 7-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year
2004-04-23
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Entrez gene record
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RefSeq identity
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Classification
Gene info
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Identity
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Gene
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Long gene name
microRNA 329-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year
2005-07-11
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Entrez gene record
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RefSeq identity
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Classification
Gene info
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Identity
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Gene
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Long gene name
microRNA 512-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year
2005-07-15
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Entrez gene record
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RefSeq identity
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Classification
Gene info
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Identity
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Gene
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Long gene name
microRNA 521-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year
2005-07-15
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Entrez gene record
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RefSeq identity
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Classification
Gene info
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Identity
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Gene
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Long gene name
microRNA 1289-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year
2008-11-03
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Entrez gene record
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RefSeq identity
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Classification
Gene info
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Identity
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Gene
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Long gene name
microRNA 509-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year
2007-10-24
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Entrez gene record
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RefSeq identity
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Classification
Gene info
Gene info
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Identity
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Gene
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Long gene name
RNA, U6 small nuclear 2
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Synonyms
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Locus
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Discovery year
2008-06-10
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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