Rabbit anti Lyosphospholipid Phosphatase (LPP) 3
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Catalog numberX1529P
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PricePlease ask
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Size100 μg
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CategoryPrimary Antibodies
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Long descriptionPhosphatidic acid phosphatase type 2 (PAP2) was originally identified as a plasma membrane enzyme that catalyses the dephosphorylation of the putative second messenger, phosphatidic acid (PA) to diacylglycerol (DG) [1]. Subsequently, multiple isoforms of PAP2 were cloned [2-5]. It was found that these enzymes dephosphorylate a number of lipid phosphates in vitro other than PA, including the potent bioactive lipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Therefore, they have been renamed lipid phosphate phosphatases (LPPs). Currently, there are four members of this family called LPP1, LPP1a, LPP2 and LPP3 [6]. _x000B_ S1P [7] and LPA [8] regulate the proliferation, differentiation, apoptosis and migration of cells by binding to a family of G protein-coupled receptors. Thus, EDG1/S1P1, EDG3/S1P3, EDG5/S1P2/AGR16/H218, EDG6/S1P4 and EDG8/S1P5/nrg-1 are high affinity S1P receptors [7] whereas EDG2/LPA1, EDG4/LPA2 and EDG7/LPA3 have high affinity for LPA [8]. _x000B_ Recently, the over-expression of LPP1 was shown to limit LPA-stimulated signalling in Rat2 fibroblasts [9] and LPA-stimulated DNA synthesis in HEK 293 cells [10]. Similarly, over-expression of LPP1, LPP1a and LPP2 attenuate S1P-signalling to the p42/p44 mitogen activated protein kinase cascade [11].
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Antibody come fromHybridoma produced by the fusion of splenocytes from mice immunized with intact SKBR-3 breast cancer cells and mouse myeloma cells.
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Other descriptionProvided as solution in phosphate buffered saline with 0.08% sodium azide. Ammonium Sulfate Precipitation
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ClonePolyclonal
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Antigen antibody binding interactionRabbit anti Lyosphospholipid Phosphatase (LPP) 3 Antibody
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Antibody is raised inRabbit
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Antibody s reacts withHuman
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Antibody s reacts with these speciesThis antibody doesn't cross react with other species
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Antibody s specificityNo Data Available
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ApplicationWestern Blot
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Antibody s suited forThis antibody can be used to accelerate (~50%) c-erbB-2 internatization1, inhibit (~80%) tumorigenic cell growth1, immunoprecipitation (2 µg/mg of protein lysate) and immunofluorescence. Optimal concentration should be evaluated by serial dilutions.
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Storage-20ºC
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Relevant references1. Stancovski, I et. al. 'Mechanistic aspects of the opposing effects of monoclonal antibodies to the ERBB2 receptor on tumor growth.' Proc. Natl. Acad. Sci USA, 1991, 88(19):8691-5._x000B__x000B_2. Hurwitz E et. al. 'Suppression and promotion of tumor growth by monoclonal antibodies to ErbB-2 differentially correlate with cellular uptake.' Proc. Natl. Acad. Sci USA, 1995, 92(8):3353-7._x000B_
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Protein numbersee ncbi
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WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
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AboutRabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin nameOryctolagus cuniculus
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Gene target
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Gene symbolLPP-AS1, LPP, LPP-AS2
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Short nameRabbit anti Lyosphospholipid Phosphatase (LPP) 3
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TechniqueRabbit, anti, antibody to
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HostRabbit, Rabbits
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Isotypenot specified
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Labelunlabeled
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Alternative nameproduction species: rabbit antibody to Lyosphospholipid Phosphatase (LIM domain containing preferred translocation partner in lipoma) 3
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Alternative techniquerabbit-anti, antibodies
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Alternative to gene targetLIM domain containing preferred translocation partner in lipoma, LPP and IDBG-69427 and ENSG00000145012 and 4026, zinc ion binding, nuclei, Lpp and IDBG-149949 and ENSMUSG00000033306 and 210126, LPP and IDBG-634548 and ENSBTAG00000044001 and 524132
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Gene info
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Identity
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Gene
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Long gene nameLPP antisense RNA 1
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Synonyms gene name
- LPP antisense RNA 1 (non-protein coding)
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Locus
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Discovery year2011-07-28
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Classification
- Antisense RNAs
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameLIM domain containing preferred translocation partner in lipoma
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Synonyms gene name
- LIM domain-containing preferred translocation partner in lipoma
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Synonyms name
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GenBank acession
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Locus
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Discovery year1996-07-19
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Zyxin family
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameLPP antisense RNA 2
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Synonyms gene name
- LPP antisense RNA 2 (non-protein coding)
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Synonyms
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GenBank acession
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Locus
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Discovery year2011-07-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Antisense RNAs
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
