Rabbit anti LRRK2
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Catalog numberX2733P
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PricePlease ask
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Size100 μg
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CategoryPrimary Antibodies
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Long descriptionLRRK2 is a member of the protein kinase superfamily. It contains 12 LRRÕs (leucine-rich repeats). It may play a role in the phosphorylation of proteins central to Parkinson disease. Phosphorylates PRDX3. May also have GTPase activity. Interacts with PARK2. Interacts with PRDX3. Expressed throughout the adult brain, but at a lower level than in heart and liver. Also expressed in placenta, lung, skeletal muscle, kidney and pancreas. In the brain, expressed in the cerebellum, cerebral cortex, medulla, spinal cord occipital pole, frontal lobe, temporal lobe and putamen. Expression is particularly high in brain dopaminoceptive areas. Defects in LRRK2 are the cause of Parkinson disease type 8 (PARK8). A slowly progressive neurodegenerative disorder characterized by bradykinesia, rigidity, resting tremor, postural instability, neuronal loss in the substantia nigra, and the presence of neurofibrillary MAPT (tau)-positive and Lewy bodies in some patients.
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Antibody come fromPhosphopeptide derived from the human histone H2A.x protein.
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Other descriptionProvided as solution in phosphate buffered saline with 0.08% sodium azide. Antigen Immunoaffinity Purification
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ClonePolyclonal
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Antigen antibody binding interactionRabbit anti LRRK2 Antibody
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Antibody is raised inRabbit
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Antibody s reacts withHuman
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Antibody s reacts with these speciesThis antibody doesn't cross react with other species
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Antibody s specificityNo Data Available
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ApplicationImmunohistochemistry
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Antibody s suited forAntibody can be used for Western blotting (1-5 µg/ml) and immunohistochemistry (2-5 µg/ml at pH 6.2). Optimal concentration should be evaluated by serial dilutions.
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Storage-20ºC
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Relevant references1. Paull, T.T., et al. ÔA critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damageÕ Curr. Biol., 10, 886-895 (2000)_x000B__x000B_2. Kobayashi, J., et al. ÔNBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain.Õ Curr. Biol., 12, 1846-1851 (2002)_x000B__x000B_3. Stewart, G.S., et al. ÔMDC1 is a mediator of the mammalian DNA damage checkpoint.Õ Nature, 421, 961-966 (2003)_x000B__x000B_4. Lukas, C., et al. ÔMdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention.Õ EMBO J., 23, 2674-2683 (2004)
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Protein numbersee ncbi
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WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
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AboutRabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin nameOryctolagus cuniculus
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Gene target
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Gene symbolLRRK2-DT, LRRK2
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Short nameRabbit anti LRRK2
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TechniqueRabbit, anti, antibody to
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HostRabbit, Rabbits
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Isotypenot specified
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Labelunlabeled
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Alternative nameproduction species: rabbit antibody to leucine-rich repeat kinase 2
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Alternative techniquerabbit-anti, antibodies
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Alternative to gene targetleucine-rich repeat kinase 2, LRRK2 and IDBG-27257 and ENSG00000188906 and 120892, transferase activity, Extracellular, Lrrk2 and IDBG-175625 and ENSMUSG00000036273 and 66725, LRRK2 and IDBG-633456 and ENSBTAG00000016260 and 535652
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Gene info
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Identity
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Gene
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Long gene nameLRRK2 divergent transcript
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Locus
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Discovery year2019-08-16
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Entrez gene record
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Classification
- Divergent transcripts
Gene info
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Identity
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Gene
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Long gene nameleucine rich repeat kinase 2
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Synonyms gene
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Synonyms gene name
- Parkinson disease (autosomal dominant) 8
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2004-10-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Armadillo like helical domain containing
- ROCO family
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data