Rabbit anti LRRK2

  • Catalog number
    X2733P
  • Price
    Please ask
  • Size
    100 μg
  • Category
    Primary Antibodies
  • Long description
    LRRK2 is a member of the protein kinase superfamily. It contains 12 LRRÕs (leucine-rich repeats). It may play a role in the phosphorylation of proteins central to Parkinson disease. Phosphorylates PRDX3. May also have GTPase activity. Interacts with PARK2. Interacts with PRDX3. Expressed throughout the adult brain, but at a lower level than in heart and liver. Also expressed in placenta, lung, skeletal muscle, kidney and pancreas. In the brain, expressed in the cerebellum, cerebral cortex, medulla, spinal cord occipital pole, frontal lobe, temporal lobe and putamen. Expression is particularly high in brain dopaminoceptive areas. Defects in LRRK2 are the cause of Parkinson disease type 8 (PARK8). A slowly progressive neurodegenerative disorder characterized by bradykinesia, rigidity, resting tremor, postural instability, neuronal loss in the substantia nigra, and the presence of neurofibrillary MAPT (tau)-positive and Lewy bodies in some patients.
  • Antibody come from
    Phosphopeptide derived from the human histone H2A.x protein.
  • Other description
    Provided as solution in phosphate buffered saline with 0.08% sodium azide. Antigen Immunoaffinity Purification
  • Clone
    Polyclonal
  • Antigen antibody binding interaction
    Rabbit anti LRRK2 Antibody
  • Antibody is raised in
    Rabbit
  • Antibody s reacts with
    Human
  • Antibody s reacts with these species
    This antibody doesn't cross react with other species
  • Antibody s specificity
    No Data Available
  • Application
    Immunohistochemistry
  • Antibody s suited for
    Antibody can be used for Western blotting (1-5 µg/ml) and immunohistochemistry (2-5 µg/ml at pH 6.2). Optimal concentration should be evaluated by serial dilutions.
  • Storage
    -20ºC
  • Relevant references
    1. Paull, T.T., et al. ÔA critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damageÕ Curr. Biol., 10, 886-895 (2000)_x000B__x000B_2. Kobayashi, J., et al. ÔNBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain.Õ Curr. Biol., 12, 1846-1851 (2002)_x000B__x000B_3. Stewart, G.S., et al. ÔMDC1 is a mediator of the mammalian DNA damage checkpoint.Õ Nature, 421, 961-966 (2003)_x000B__x000B_4. Lukas, C., et al. ÔMdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention.Õ EMBO J., 23, 2674-2683 (2004)
  • Protein number
    see ncbi
  • Warnings
    This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
  • About
    Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
  • Latin name
    Oryctolagus cuniculus
  • Gene target
    LRRK2  
  • Gene symbol
    LRRK2-DT, LRRK2
  • Short name
    Rabbit anti LRRK2
  • Technique
    Rabbit, anti, antibody to
  • Host
    Rabbit, Rabbits
  • Isotype
    not specified
  • Label
    unlabeled
  • Alternative name
    production species: rabbit antibody to leucine-rich repeat kinase 2
  • Alternative technique
    rabbit-anti, antibodies
  • Alternative to gene target
    leucine-rich repeat kinase 2, LRRK2 and IDBG-27257 and ENSG00000188906 and 120892, transferase activity, Extracellular, Lrrk2 and IDBG-175625 and ENSMUSG00000036273 and 66725, LRRK2 and IDBG-633456 and ENSBTAG00000016260 and 535652
Gene info
  • Identity
  • Gene
  • Long gene name
    LRRK2 divergent transcript
  • Locus
  • Discovery year
    2019-08-16
  • Entrez gene record
  • Classification
    • Divergent transcripts
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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