-
Category
Primary Antibodies
-
Long description
The calcium channel alpha2/delta subunit is a glycosylated structural subunit consisting of the alpha2 subunit and the delta peptide. There is distinctive alpha2 subunit expression in rat spinal cord and dorsal root ganglia (DRG) There are two forms of the alpha2 subunit in DRG that are different from the alpha2 subunit in other tissues examined, at least at the glycosylation level. Thus, post-translational modification may be important in tissue specific and functional expression of the alpha2/delta subunit (2). alpha2/delta and beta1b interact with alpha1G to increase trafficking of, or stabilize, functional alpha1G channels expressed at the plasma membrane.(3)_x000B_
-
Antibody come from
Recombinant protein derived from the amino acids 1-200 of yeastt TUP1 protein
-
Other description
Provided as solution in phosphate buffered saline with 0.08% sodium azide. Ammonium Sulfate Precipitation
-
Clone
Polyclonal
-
Antigen antibody binding interaction
Rabbit anti L-type calcium channel alpha2/delta subunit Antibody
-
Antibody is raised in
Rabbit
-
Antibody s reacts with
Human, Rat
-
Antibody s reacts with these species
This antibody doesn't cross react with other species
-
Antibody s specificity
No Data Available
-
Application
Western Blot
-
Antibody s suited for
Antibody can be used for Western blotting (5-10 µg/ml). Optimal concentration should be evaluated by serial dilutions.
-
Storage
-20ºC
-
Relevant references
1. Bone, J.R. and Roth, S.Y. 'Recruitment of the yeast Tup1p-Ssn6p repressor is associated with localized decreases in histone acetylation.' J. Biol. Chem 2001, 276, 1808-1813_x000B__x000B_2. Watson, A.D., et al. 'Ssn6-Tup1 interacts with class I histone deacetylase required for repression.' Genes and Development 2000, 14, 2737-2744_x000B__x000B_3. Yang, X., et al. 'Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: Coupling protein O-GlcNAcylation to transcriptional repressor.' Cell 2002, 110, 69-80_x000B__x000B_4. DeSilva, H., et al. 'Functional dissection of yeast Hir1p, a WD repeat-containing transcriptional corepressor.' Genetics 1998, 148, 657-667_x000B__x000B_
-
Protein number
see ncbi
-
Warnings
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
-
-
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
-
About
Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
-
Latin name
Oryctolagus cuniculus
