Rabbit anti Kv3.1b Potassium Channel

  • Catalog number
    X1504P
  • Price
    Please ask
  • Size
    100 μg
  • Category
    Primary Antibodies
  • Long description
    The Kv3.1b potassium channel is a voltage-gated channel protein which belongs to the delayed rectifier class and to the Shaw potassium channel subfamily. Potassium channels are mainly found in plasma membranes but are not generally distributed over the cell surface. Potassium channels catalyze the rapid permeation of potassium ions while rejecting biologically abundant potential competitors such as sodium, calcium and magnesium. Ion selectivity and high through put rate of potassium channels is accomplished by precise co-ordination of dehydrated potassium by the protein and multiple ion occupancy within the permeation pathway. All potassium channels carry out the formation of a transmembrane leak specific for potassium ions. Since cells almost universally maintain cytoplasmic potassium concentrations higher than those extracellularly, the opening of a potassium channel implies a negative ongoing change in electrical voltage across the cell membrane. This may result in termination of the action potential of electrically excitable cells including nerve, muscle and pancreatic beta cells. In nonÐexcitable cells, potassium channels play important roles in the cellular potassium recycling required for electrolyte balance effected by the renal epithelium.
  • Antibody come from
    Synthetic peptide derived from the rat calcium channel gamma4 subunit conjugated to KLH
  • Other description
    Provided as solution in phosphate buffered saline with 0.08% sodium azide. Ammonium Sulfate Precipitation
  • Clone
    Polyclonal
  • Antigen antibody binding interaction
    Rabbit anti Kv3.1b Potassium Channel Antibody
  • Antibody is raised in
    Rabbit
  • Antibody s reacts with
    Human, Mouse, Rat
  • Antibody s reacts with these species
    This antibody doesn't cross react with other species
  • Antibody s specificity
    No Data Available
  • Application
    Western Blot
  • Antibody s suited for
    This antibody can be used for Western blotting at 5-10 µg/ml. Optimal concentration should be evaluated by serial dilutions.
  • Storage
    -20ºC
  • Relevant references
    1. Hofmann F, et al. Rev Physiol Biochem Pharmacol 1999, 139:33-87_x000B__x000B_2. Singer D, et al. Science 1991, 253:1553-7_x000B__x000B_3. Letts VA, et al. Nat Genet 1998, 19:340-7_x000B__x000B_4. Kang, M.G., et al. J. Biol. Chem. 2001, 276: 32917-24_x000B__x000B_5. Sharp, A.H., et al. Neuroscience 2001, 105:599-617_x000B__x000B_6. Steinlein OK, Noebels JL Curr Opin Genet Dev 2000,10:286-91_x000B__x000B_7. Chen, L., et al. 'Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms.' Nature 2000, 408: 936-943.
  • Protein number
    see ncbi
  • Warnings
    This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
  • About
    Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
  • Latin name
    Oryctolagus cuniculus
  • Gene target
    Kv3   Potassium   Channel  
  • Short name
    Rabbit anti Kv3 1b Potassium Channel
  • Technique
    Rabbit, anti, antibody to
  • Host
    Rabbit, Rabbits
  • Isotype
    not specified
  • Label
    unlabeled
  • Alternative name
    production species: rabbit antibody to Kv3.1b Potassium Channel
  • Alternative technique
    rabbit-anti, antibodies
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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