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Category
Primary Antibodies
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Long description
The Kv3.1b potassium channel is a voltage-gated channel protein which belongs to the delayed rectifier class and to the Shaw potassium channel subfamily. Potassium channels are mainly found in plasma membranes but are not generally distributed over the cell surface. Potassium channels catalyze the rapid permeation of potassium ions while rejecting biologically abundant potential competitors such as sodium, calcium and magnesium. Ion selectivity and high through put rate of potassium channels is accomplished by precise co-ordination of dehydrated potassium by the protein and multiple ion occupancy within the permeation pathway. All potassium channels carry out the formation of a transmembrane leak specific for potassium ions. Since cells almost universally maintain cytoplasmic potassium concentrations higher than those extracellularly, the opening of a potassium channel implies a negative ongoing change in electrical voltage across the cell membrane. This may result in termination of the action potential of electrically excitable cells including nerve, muscle and pancreatic beta cells. In nonÐexcitable cells, potassium channels play important roles in the cellular potassium recycling required for electrolyte balance effected by the renal epithelium.
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Antibody come from
Synthetic peptide derived from the rat calcium channel gamma4 subunit conjugated to KLH
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Other description
Provided as solution in phosphate buffered saline with 0.08% sodium azide. Ammonium Sulfate Precipitation
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Clone
Polyclonal
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Antigen antibody binding interaction
Rabbit anti Kv3.1b Potassium Channel Antibody
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Antibody is raised in
Rabbit
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Antibody s reacts with
Human, Mouse, Rat
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Antibody s reacts with these species
This antibody doesn't cross react with other species
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Antibody s specificity
No Data Available
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Application
Western Blot
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Antibody s suited for
This antibody can be used for Western blotting at 5-10 µg/ml. Optimal concentration should be evaluated by serial dilutions.
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Storage
-20ºC
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Relevant references
1. Hofmann F, et al. Rev Physiol Biochem Pharmacol 1999, 139:33-87_x000B__x000B_2. Singer D, et al. Science 1991, 253:1553-7_x000B__x000B_3. Letts VA, et al. Nat Genet 1998, 19:340-7_x000B__x000B_4. Kang, M.G., et al. J. Biol. Chem. 2001, 276: 32917-24_x000B__x000B_5. Sharp, A.H., et al. Neuroscience 2001, 105:599-617_x000B__x000B_6. Steinlein OK, Noebels JL Curr Opin Genet Dev 2000,10:286-91_x000B__x000B_7. Chen, L., et al. 'Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms.' Nature 2000, 408: 936-943.
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Protein number
see ncbi
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Warnings
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
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About
Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin name
Oryctolagus cuniculus