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Immunogen
A phospho-specific peptide corresponding to residues surrounding Tyr217 and Ser218of human RSK3 (AA214-221)
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Antibody s target
Human RSK3 (pTyr217 + pSer218)
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Antibody s full description
Rabbit Anti-Human RSK3 (pTyr217 + pSer218) Polyclonal
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Antibody s category
Polyclonal Antibodies
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Antibody s other name
RPS6KA2 Antibody, RSK 3 Antibody, RSK Antibody, RSK-3 Antibody, S6K alpha Antibody, S6K alpha 2 Antibody, S6K-alpha-2 Antibody, 90 kDa ribosomal protein S6 kinase 2 Antibody, Ribosomal protein S6 kinase alpha-2 Antibody, ribosomal protein S6 kinase, 90kDa, polypeptide 2 Antibody, Ribosomal S6 kinase 3 Antibody, HU 2 Antibody, KS6A2_HUMAN Antibody, MAP kinase activated protein kinase 1c Antibody, MAP kinase-activated protein kinase 1c Antibody, MAPK-activated protein kinase 1c Antibody, MAPKAP kinase 1c Antibody, MAPKAPK-1c Antibody, MAPKAPK1C Antibody, Mitogen.activated protein kinase-activated protein kinase 1C Antibody, p90 RSK3 Antibody, p90-RSK 2 Antibody, p90RSK2 Antibody, pp90RSK3 Antibody
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Verified applications
WB, AM
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Raised in
Rabbit
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Antibody s reactivity
Human
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Antibody s recommended dilutions for use
WB (1:250); optimal dilutions for assays should be determined by the user.
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Antibody s purified from
Peptide Affinity Purified
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Recommended buffer for storage
PBS pH7.4, 50% glycerol, 0.025% Thimerosal
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Antibody s concentration
See included datasheet or contact our support service
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Antibody s specificity
Detects 83.239 kDa.
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Storage recommendations
-20°C
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Shipping recommendations
Blue Ice or 4°C
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Certificate of analysis
A 1:250 dilution of SPC-1080 was sufficient for detection of RSK3 (pTyr217 + pSer218) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
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Antibody in cell
Nucleus, Cytoplasm
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Tissue specificity
Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.
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Scientific context
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumour suppressor in epithelial ovarian cancer cells.
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Bibliography
Refer to PubMed
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Released date
29/Aug/2016
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NCBI number
NP_066958
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Gene number
6196
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Protein number
Q15349
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Antibody s datasheet
Contact our support service to receive datasheet or other technical documentation.
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Representative figure link
No Data Available
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
1.4
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Net weight g
0.1
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Stock availabilit
In Stock
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Test
StressMark antibodies supplies antibodies that are for research of human proteins.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Group
Polyclonals and antibodies
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About
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera. Rabbits are used for polyclonal antibody production by StressMark antibodies. Rabbit antibodies are very stable and can be stored for several days at room temperature. StressMark antibodies adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin name
Oryctolagus cuniculus
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Gene target
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Gene symbol
RPS6KA2, APC
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Short name
Rabbit Anti- RSK3 (pTyr217 + pSer218) Polyclonal: APC
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Technique
anti-Human, Polyclonal, Rabbit, anti-, anti, antibody to, antibodies, antibodies against human proteins, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
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Host
Rabbit, Rabbits
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Isotype
Immunoglobulin
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Label
APC
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Species
Human, Humans
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Alternative name
production species: rabbit Antibody toHuman RSK3 (pTyr217 + pSer218) polyclonal: adenomatous polyposis coli
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Alternative technique
polyclonals, rabbit-anti, antibodies
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Alternative to gene target
adenomatous polyposis coli, BTPS2 and DP2 and DP2.5 and DP3 and GS and PPP1R46, APC and IDBG-37007 and ENSG00000134982 and 324, microtubule plus-end binding, nuclei, Apc and IDBG-134573 and ENSMUSG00000005871 and 11789, BT.25770 and IDBG-644937 and ENSBTAG00000018852 and 533233
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