Rabbit Anti-Human MEK4 Polyclonal: RPE
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Catalog numberSPC-1173D-RPE
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PricePlease ask
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Size100 µl
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ImmunogenSynthetic peptide corresponding to the kinase catalytic subdomain 11 of human MEK4 (AA 347-363)
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Antibody s targetHuman MEK4
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Antibody s full descriptionRabbit Anti-Human MEK4 Polyclonal
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Antibody s categoryPolyclonal Antibodies
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Antibody s other nameC-JUN N-terminal kinase kinase 1 antibody, Dual specificity mitogen activated protein kinase kinase 4 antibody, Dual specificity mitogen-activated protein kinase kinase 4 antibody, JNK Activated Kinase 1 antibody, JNKK antibody, JNKK1 antibody, MAP kinase kinase 4 antibody, Map2k4 antibody, MAPK ERK kinase 4 antibody, MAPK/ERK kinase 4 antibody, MAPKK 4 antibody, MEK 4 antibody, MEK4 antibody, Mitogen activated protein kinase kinase 4 antibody, MKK4 antibody, MP2K4_HUMAN antibody, PRKMK4 antibody, SAPK ERK kinase 1 antibody, SAPKK 1 antibody, SEK1 antibody, SERK1 antibody, SKK1 antibody, Stress activated protein kinase kinase 1 antibody
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Verified applicationsWB, AM
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Raised inRabbit
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Antibody s reactivityHuman, Mouse, Frog
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Antibody s recommended dilutions for useWB (1:250); optimal dilutions for assays should be determined by the user.
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Antibody s purified fromPeptide Affinity Purified
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Recommended buffer for storagePBS pH7.4, 50% glycerol, 0.025% Thimerosal
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Antibody s concentrationSee included datasheet or contact our support service
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Antibody s specificityDetects 44kDa.
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Storage recommendations-20°C
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Shipping recommendationsBlue Ice or 4°C
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Certificate of analysisA 1:250 dilution of SPC-1173 was sufficient for detection of MEK4 in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
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Antibody in cellCytoplasm, Nucleus
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Tissue specificityAbundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
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Scientific contextMAP2K4 is a protein-serine/threonine/tyrosine kinase. Involved in MAPK signalling in response to stressors or mitogens. It signals through JNK1/JNK2, ERK1/ERK2, p38 and more. It has arole in maintaining peripheral lymphoid homeostasis and apoptosis. Mutations and deletions of this genes leads to dysregulated JNK signalling and promotes oncogenesis.
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BibliographyRefer to PubMed
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Released date29/Aug/2016
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NCBI numberNP_003001
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Gene number6416
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Protein numberP45985
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Antibody s datasheetContact our support service to receive datasheet or other technical documentation.
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Representative figure linkNo Data Available
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg1.4
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Net weight g0.1
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Stock availabilitIn Stock
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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TestStressMark antibodies supplies antibodies that are for research of human proteins.
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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GroupPolyclonals and antibodies
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AboutPolyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera. Rabbits are used for polyclonal antibody production by StressMark antibodies. Rabbit antibodies are very stable and can be stored for several days at room temperature. StressMark antibodies adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin nameOryctolagus cuniculus
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Gene target
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Gene symbolRPE, MAP2K4
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Short nameRabbit Anti- MEK4 Polyclonal: RPE
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Techniqueanti-Human, Polyclonal, Rabbit, anti-, anti, antibody to, antibodies, antibodies against human proteins, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
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HostRabbit, Rabbits
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IsotypeImmunoglobulin
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LabelRPE
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SpeciesHuman, Humans
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Alternative nameproduction species: rabbit Antibody toHuman MEK4 polyclonal: RPE
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Alternative techniquepolyclonals, rabbit-anti, antibodies
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Gene info
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Identity
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Gene
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Long gene nameribulose-5-phosphate-3-epimerase
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Locus
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Discovery year2001-06-22
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Entrez gene record
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemitogen-activated protein kinase kinase 4
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Synonyms gene
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Synonyms
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GenBank acession
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Locus
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Discovery year1997-11-11
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Entrez gene record
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Pubmed identfication
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Classification
- Mitogen-activated protein kinase kinases
- MicroRNA protein coding host genes
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data