Rabbit anti Integrin antibody beta 1 (fibronectin receptor antibody beta polypeptide antibody antigen CD29 includes MDF2 antibody MSK12) (ITGB1)

  • Catalog number
    X2190P
  • Price
    Please ask
  • Size
    50 μg
  • Category
    Primary Antibodies
  • Long description
    Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis.
  • Antibody come from
    C-terminal domain of human
  • Other description
    Phosphate buffered saline containing 0.1% sodium azide. Immunoaffinity Purification
  • Clone
    Polyclonal
  • Antigen antibody binding interaction
    Rabbit anti Integrin antibody beta 1 (fibronectin receptor antibody beta polypeptide antibody antigen CD29 includes MDF2 antibody MSK12) (ITGB1) Antibody
  • Antibody is raised in
    Rabbit
  • Antibody s reacts with
    Human
  • Antibody s reacts with these species
    This antibody doesn't cross react with other species
  • Antibody s specificity
    No Data Available
  • Application
    Immunohistochemistry-Paraffin
  • Antibody s suited for
    Optimal concentration should be evaluated by serial dilutions.
  • Storage
    Long term: -70ºC; Short term: +4ºC
  • Relevant references
    no information yet
  • Protein number
    see ncbi
  • Warnings
    This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antigens are peptides or recombinant or native dependent on the production method. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
  • Properties
    If you buy Antibodies supplied by nordc they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • About
    Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
  • Latin name
    Oryctolagus cuniculus
  • French translation
    anticorps
  • Gene target
  • Gene symbol
    ITGB1, ITGB1-DT, IATPR
  • Short name
    Rabbit anti Integrin antibody beta 1 (fibronectin receptor antibody beta polypeptide antibody antigen CD29 includes MDF2 antibody MSK12) (ITGB1)
  • Technique
    Antibody, antigen, Rabbit, anti, antibody to, antibodies against human proteins, antibodies for, antigenes
  • Host
    Rabbit, Rabbits
  • Isotype
    not specified
  • Label
    unlabeled
  • Alternative name
    production species: rabbit antibody to Integrin (antibody to-) b 1 (fibronectin receptor (antibody to-) b multipeptide (antibody to-) protein CD29 includes MDF2 (antibody to-) MSK12) (integrin, b 1 (fibronectin receptor, b polypeptide, antigen CD29 includes MDF2, MSK12))
  • Alternative technique
    antibodies, antigenes, rabbit-anti
  • Alternative to gene target
    integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12), CD29 and FNRB and GPIIA and MDF2 and MSK12 and VLA-BETA and VLAB, ITGB1 and IDBG-68302 and ENSG00000150093 and 3688, alpha-actinin binding, Cell surfaces, Itgb1 and IDBG-201159 and ENSMUSG00000025809 and 16412, ITGB1 and IDBG-637396 and ENSBTAG00000015910 and 281876
Gene info
  • Identity
  • Gene
  • Long gene name
    integrin subunit beta 1
  • Synonyms gene
  • Synonyms gene name
    • integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1988-06-27
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • CD molecules
    • Integrin beta subunits
  • VEGA ID
Gene info
  • Identity
  • Gene
  • Long gene name
    ITGB1 divergent transcript
  • Locus
  • Discovery year
    2017-09-01
  • Entrez gene record
  • Classification
    • Divergent transcripts
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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