Rabbit anti DAP12

  • Catalog number
    X1588P
  • Price
    Please ask
  • Size
    100 μg
  • Category
    Primary Antibodies
  • Long description
    DAP12 is a transmembrane adaptor protein that is non-covalently associated with several cell surface receptors on natural killer (NK), myeloid, and presumably neuronal cells (1,2). DAP12 contains an ITAM domain that preferentially recruits the protein tyrosine kinase Syk to initiate signal transduction (3). Deficiency of DAP12 results in reduced antigen presentation function by myeloid cells and defects in function of certain NK cell receptors in mice (4,5), as well as presenile dementia and bone cysts in humans (6).
  • Antibody come from
    Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with live human breat cancer cells (cell line ZR-75-1) and mouse myeloma SP2 cells.
  • Other description
    Provided as solution in phosphate buffered saline with 0.08% sodium azide. Ammonium Sulfate Precipitation
  • Clone
    Polyclonal
  • Antigen antibody binding interaction
    Rabbit anti DAP12 Antibody
  • Antibody is raised in
    Rabbit
  • Antibody s reacts with
    Human, Mouse
  • Antibody s reacts with these species
    This antibody doesn't cross react with other species
  • Antibody s specificity
    No Data Available
  • Application
    Western Blot, Immunoprecipitation
  • Antibody s suited for
    The antibody reacts with the extracellular 12-mer GVTSAPDTRPAP epitope of the MUC-1 tandem repeat.Antibody can be used for immunohistochemistry on frozen and paraffin embedded tissues and ELISA. Optimal concentration should be evaluated by serial dilutions.
  • Storage
    -20ºC
  • Relevant references
    1. Schol, D.J. et al., Epitope fingerprinting using overlapping 20-mer peptides of the MUC 1 tandem repeat sequence. Tumor Biol. Suppl. 1998: 19, 35-45._x000B_ _x000B_2. Price, M.R. et al., Analysis of 56 monoclonal antibodies against the MUC1 mucin.Tumor Biol. Suppl. 1998: 19, 1-20. _x000B__x000B_3. Cao, Y. et al., Immunohistochemical characterization of a panel of 56 anti bodies with normal human small intestine, colon, and breastÊ tissues. Tumor Biol. Suppl. 1998: 19, 88-99 _x000B_
  • Protein number
    see ncbi
  • Warnings
    This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
  • About
    Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
  • Latin name
    Oryctolagus cuniculus
  • Gene target
    DAP12  
  • Gene symbol
    TYROBP
  • Short name
    Rabbit anti DAP12
  • Technique
    Rabbit, anti, antibody to
  • Host
    Rabbit, Rabbits
  • Isotype
    not specified
  • Label
    unlabeled
  • Alternative name
    production species: rabbit antibody to DAP12
  • Alternative technique
    rabbit-anti, antibodies
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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