(R)-N-(2,4-Difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,3,4,8-tetrahydro-1H-pyrido[1,2-a]pyrazine-7-carboxamide

• Catalog number
  D447205
• Price
  Please ask
• Size
  1 mg

• Chemical available in other sizes
  Please inquire size and price
• Stock availability
  Please Inquire
• Cas number
  This product doesn't have CAS Number
• Chemical s molecular weight
  419.38
• Chemical s main applications
  (R)-N-(2,4-Difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,3,4,8-tetrahydro-1H-pyrido[1,2-a]pyrazine-7-carboxamide is impurity E of Dolutegravir (D528800), which is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
• Other name
  Dolutegravir impurity E
• Chemical s formula
  C20H19F2N3O5
• Physical properties
  No Data Available
• Melting temperature
  No Data Available
• Boiling temperature
  No Data Available
• Chemical s soluble in
  No Data Available
• Stability conditions
  No Data Available
• Storage
  No Data Available
• Chemical s specifications

• Gene target
  4-Difluorobenzyl   9-hydroxy-2   4-hydroxybutan-2-yl   8-dioxo-2   8-tetrahydro-1H-pyrido[1   2-a]pyrazine-7-carboxamide  
• Gene symbol
  VSIR, MIR7-2, TRN-GTT2-7, TRI-AAT7-2, PIRC34, FAM3A, H3-7, PIRC33
• Short name
  (R)-N-(2 4-Difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1 8-dioxo-2 3 4 8-tetrahydro-1H-pyrido[1 2-a]pyrazine-7-carboxamide
• Alternative name
  (R)-N-(2,4-Difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,3,4,8-tetrahydro-1H-pyrido[1,2-a]pyrazine-7-carboxamide

Gene info

• Identity
  HGNC:30085
• Gene
  VSIR
• Long gene name
  V-set immunoregulatory receptor
• Synonyms gene
  • C10orf54
• Synonyms gene name
  • chromosome 10 open reading frame 54
• Synonyms
  • SISP1
  • GI24
  • B7-H5
  • B7H5
  • VISTA
  • PD-1H
  • Dies1
• Synonyms name
  • stress induced secreted protein 1
  • V-domain Ig suppressor of T cell activation
  • PDCD1 homolog
• GenBank acession
  • AF193048
• Locus
  10q22.1
• Discovery year
  2005-10-06
• Entrez gene record
  64115
• Pubmed identfication
  • 12975309
  • 24691993
  • 25279955
• RefSeq identity
  • NM_022153
• Classification
  • B7 family
  • V-set domain containing
• VEGA ID
  OTTHUMG00000018426

Gene info

• Identity
  HGNC:31639
• Gene
  MIR7-2
• Long gene name
  microRNA 7-2
• Synonyms gene
  • MIRN7-2
• Synonyms
  • hsa-mir-7-2
• Locus
  15q26.1
• Discovery year
  2004-04-23
• Entrez gene record
  407044
• RefSeq identity
  • NR_029606
• Classification
  • MicroRNA MIR7 family

Gene info

• Identity
  HGNC:54714
• Gene
  TRN-GTT2-7
• Long gene name
  tRNA-Asn (anticodon GTT) 2-7
• Synonyms
  • tRNA-Asn-GTT-2-7
• Locus
  1q21.1
• Discovery year
  2019-12-06
• Entrez gene record
  7214
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34970
• Gene
  TRI-AAT7-2
• Long gene name
  tRNA-Ile (anticodon AAT) 7-2
• Synonyms gene
  • TRNAI25
• Synonyms gene name
  • transfer RNA isoleucine 25 (anticodon AAU)
  • transfer RNA-Ile (AAT) 7-2
• Synonyms
  • tRNA-Ile-AAT-7-2
• GenBank acession
  • HG983854
• Locus
  6p22.2
• Discovery year
  2008-08-29
• Entrez gene record
  107986683
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:37538
• Gene
  PIRC34
• Long gene name
  piwi-interacting RNA cluster 34
• Locus
  7
• Discovery year
  2009-11-05
• Entrez gene record
  100313890
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:13749
• Gene
  FAM3A
• Long gene name
  FAM3 metabolism regulating signaling molecule A
• Synonyms gene name
  • family with sequence similarity 3 member A
• Synonyms
  • DXS560S
  • 2-19
  • XAP-7
• GenBank acession
  • X74610
• Locus
  Xq28
• Discovery year
  2002-06-18
• Entrez gene record
  60343
• Pubmed identfication
  • 27688071
  • 26939760
  • 26492522
• VEGA ID
  OTTHUMG00000013418
• Locus Specific Databases
  • Global Variome shared LOVD

Gene info

• Identity
  HGNC:32060
• Gene
  H3-7
• Long gene name
  H3.7 histone (putative)
• Synonyms gene
  • HIST2H3PS2
  • H3-2
• Synonyms gene name
  • histone 2, H3, pseudogene 2
  • histone cluster 2, H3, pseudogene 2
  • histone cluster 2 H3 pseudogene 2
  • H3.2 histone (putative)
• Synonyms
  • p06
  • H3.7
• GenBank acession
  • AL109948
• Locus
  1q21.1
• Discovery year
  2006-06-12
• Entrez gene record
  440686
• Pubmed identfication
  • 28374988
• RefSeq identity
  • NM_001355409
• Classification
  • H3 histones
• VEGA ID
  OTTHUMG00000041033

Gene info

• Identity
  HGNC:37537
• Gene
  PIRC33
• Long gene name
  piwi-interacting RNA cluster 33
• Locus
  7
• Discovery year
  2009-11-05
• Entrez gene record
  100313854
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

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