PYR 41 for cell activation

PYR 41 for cell activation is available 2 times from Biovision labs

1925-5 | PYR-41 for cell activationsize: 5 mg | 174.18 USD

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1925-25 | PYR-41 for cell activationsize: 25 mg | 513.13 USD

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  • Description
    Cell-permeable. An irreversible ubiquitin-activating enzyme (E1) inhibitor (IC₅₀ < 10 μM). Blocks ubiquitylation and prevents ubiquitin-mediated proteasomal degradation. Inhibits NF-κB activation, blocks degradation of p53, increases p21 levels and induces apoptosis in vitro. Also causes an increase in sumoylation of proteins.
  • Peptide sequence
    N/A
  • CAS number
    418805-02-4
  • Molecular weight
    371.3
  • Category
    Biochemicals
  • Other name
    4-[4-[(5-Nitro-2-furanyl)methylene]-3,5-dioxo-1-pyrazolidinyl]benzoic acid ethyl ester
  • Molecular formula
    C₁₇H₁₃N₃O₇
  • Physical appearance
    Brown solid
  • Supplied with
    N/A
  • Is this a salt?
    No
  • Is it cell-permeable?
    Yes
  • Purification
    ≥98% by TLC
  • Reconstitute instructions
    DMSO (~25 mg/ml)
  • Storage condition
    -20°C
  • Shipping condition
    gel pack
  • Maximum time for storage
    36 months
  • Storage instructions
    Protect from light and air
  • Additional description
    For cells, cell lines and tissues in culture till half confluency.
  • Gene target
  • Short name
    PYR-41 for activation
  • Technique
    activation
  • Alternative name
    PYR-41 to measure cellular activation
  • Tissue
    cell
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