Puromycin HCl, Translation inhibitor

• Catalog number
  SIH-248-250MG
• Price
  Please ask
• Size
  250 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  58-58-2
• Description
  Translation inhibitor
• Molecular weight
  544,43 g/mol
• Primary research fields
  Cancer, Apoptosis
• Other name
  3'-Deoxy-N,N-dimethyl-3'-[(O-methyl-L-tyrosyl)amino]adenosine
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C22H29N7O5•2HCl
• Origin
  Synthetic
• Purity pourcentage
  >98% (TLC); NMR (Conforms)
• Soluble in
  May be dissolved in DMSO (50 mg/ml); or water (50 mg/ml)
• Physical appearance
  Off-white powder
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
• PubChem number
  5891
• Scientific context
  Puromycin is an antibiotic that is a protein synthesis inhibitor that causes premature chain termination during translation taking place in the ribosome. Part of the molecule resembles the 3’ end of the tRNA. It enters the A site and transfers to the growing chain, causing the premature release. It is not selective for either prokaryotes or eukaryotes.
• Bibliography
  1.  Azzam and Algranati. (1973) Proc Natl Acad Sci. 70: 3866.
• Release date
  16-May-2011
• PubMed number
  25756236|24637494
• Tested applications
  Cell selection media|siRNA selection media
• Tested reactivity
  Human|Human
• Representative figure link
• Representative figure legend
  Chemical structure of Puromycin HCl (SIH-248), a Translation inhibitor. CAS #: 58-58-2. Molecular Formula: C22H29N7O5 x 2HCl. Molecular Weight: 544.43 g/mol. Chemical structure of Puromycin HCl, a Translation inhibitor (SIH-248). CAS # 58-58-2. Molecular Formula: C22H29N7O5 x 2HCl.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.25
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Puromycin   HCl   Translation   inhibitor  
• Short name
  Puromycin HCl, Translation inhibitor
• Alternative name
  Puromycin HCl, Translation suppressor

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