PTP1B Antibody Conjugated
7x PTP1B Antibody Conjugated found in Bioss Primary Conjugated Antibodies
- CategoryConjugated Primary Antibodies
- Host OrganismRabbit (Oryctolagus cuniculus)
- Target AntigenPTP1B
- SpecificityThis is a highly specific antibody against PTP1B.
- Modification siteNone
- ClonePolyclonal antibody
- Concentration1ug per 1ul
- Subcellular locationCytoplasm
- SourceKLH conjugated synthetic peptide derived from human PTP-1B
- Gene ID number5770
- Swiss ProtP18031
- CrossreactivityHuman, Mouse, Rat
- Crossreactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
- Antigen backgroundTyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
- Purification methodThis antibody was purified via Protein A.
- SynonymsPTP1B; Tyrosine-protein phosphatase non-receptor type 1; Protein-tyrosine phosphatase 1B; PTP-1B; PTPN1
- Gene target
- Alternative techniqueantibodies
bs-0182R-Biotin | PTP1B Antibody, Biotin Conjugatedsize: 0.1ml | 408.09 USD
bs-0182R-Cy3 | PTP1B Antibody, Cy3 Conjugatedsize: 0.1ml | 428.93 USD
bs-0182R-Cy5 | PTP1B Antibody, Cy5 Conjugatedsize: 0.1ml | 428.93 USD
bs-0182R-Cy5.5 | PTP1B Antibody, Cy5.5 Conjugatedsize: 0.1ml | 428.93 USD
bs-0182R-Cy7 | PTP1B Antibody, Cy7 Conjugatedsize: 0.1ml | 428.93 USD
bs-0182R-FITC | PTP1B Antibody, FITC Conjugatedsize: 0.1ml | 408.09 USD
- Catalog numberbs-0182R-FITC
- Price408.09 USD
- Long namePTP1B Polyclonal Antibody, FITC Conjugated
- Tested applicationsIF(IHC-P)
- Recommended dilutionsIF(IHC-P)(1:50-200)
- Storage conditionsKeep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
- Excitation Emission494nm/518nm
- PropertiesIf you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS. When excited at 488 nanometers, FITC has a green emission that's usually collected at 530 nanometers, the FL1 detector of a FACSCalibur or FACScan. FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light. For fluorescent microscopy applications, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept. Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes.
- Additional conjugationAnti-FITC Antibody
- French translationanticorps
- Short namePTP1B Antibody, FITC Conjugated
- TechniqueAntibody, antibodies against human proteins, antibodies for, antibody Conjugates, Fluorescein
- Alternative namePTP1B (Antibody to), fluorecein coupled
1. Gene info
- Long gene nameprotein tyrosine phosphatase, non-receptor type 1
- Synonyms gene
- Discovery year1991-09-13
- Entrez gene record
- Pubmed identfication
- Protein tyrosine phosphatases, non-receptor type
- Havana BLAST/BLAT
- ConceptScope note:Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
- Tree numbers
- Qualifiersclassification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
- PubMedWe show that PIAS1, which functions as a small ubiquitin-like modifier (SUMO) E3 ligase, associates with PTP1B in mammalian fibroblasts and catalyses sumoylation of PTP1B.Liver PTP1B plays an important role in glucose and lipid metabolism, independent of alterations in adiposity; inhibition of PTP1B in peripheral tissues may be useful for the treatment of metabolic syndrome.Fully differentiated PTP1B(-/-) brown adipocytes were resistant to tumor necrosis factor (TNFalpha)-induced apoptosis.These data show that PTP1B in proopiomelanocortin neurons plays a role in short-term cold-induced reduction of spontaneous physical activityData suggest that PTP1B is important component in regulation of energy balance by pro-opiomelanocortin-positive neurons in the hindbrain. PTP1B knockout mice are hypersensitive to administration of leptin (or appetite depressants) to the hindbrain.Fumosorinone increased glucose uptake and improved insulin resistance by down-regulating the expression of PTP1B and activating the insulin signaling pathway, suggesting that it may possess antidiabetic properties.PTP1B/RNF213/alpha-KGDD pathway is critical for survival of HER2(+) breast cancer, and possibly other malignancies, in the hypoxic tumour microenvironment
- Gene ontology - Biological process
- Gene ontology - Cellular component
- Gene ontology - Molecular function
- Entrez Gene
bs-0182R-HRP | PTP1B Antibody, HRP Conjugatedsize: 0.1ml | 428.93 USD
Supplier:Bioss Primary Conjugated Antibodies