Category Conjugated Primary Antibodies
Host Organism Rabbit (Oryctolagus cuniculus)
Target Antigen PTP1B
Specificity This is a highly specific antibody against PTP1B.
Modification site None
Clone Polyclonal antibody
Concentration 1ug per 1ul
Subcellular location Cytoplasm
Source KLH conjugated synthetic peptide derived from human PTP-1B
Gene ID number 5770
Swiss Prot P18031
Crossreactivity Human, Mouse, Rat
Crossreactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Antigen background Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
Purification method This antibody was purified via Protein A.
Synonyms PTP1B; Tyrosine-protein phosphatase non-receptor type 1; Protein-tyrosine phosphatase 1B; PTP-1B; PTPN1