PSCDBP/CYTIP Antibody

• Catalog number
  bs-11062R
• Price
  Please ask
• Size
  0.1ml

• Long name
  PSCDBP/CYTIP Primary Polyclonal Antibody
• Also known as
  PSCDBP/CYTIP PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  PSCDBP/CYTIP
• Specificity
  This is a highly specific antibody against PSCDBP/CYTIP.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PSCDBP/CYTIP
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  CYTIP is a cytoplasmic protein that is involved in lymphocytic cell adhesion. Expressed primarily in hematopoetic cells, CYTIP regulates the activity of cytohesin-1 (an integrin-activating protein involved in cell adhesion) by mediating its recruitment to the leukocyte membrane. Through its ability to bind cytohesin-1, CYTIP is able to sequester it to the cytoplasm, thereby preventing cytohesin-1 translocation to lymphocytes and interrupting the flow of information in the cell adhesion pathway. CYTIP can be recruited from the cytoplasm to the membrane by leukocyte integrins which interact with CYTIP through its PDZ domain. After membrane translocation, CYTIP can be re-located to the cytoplasm via exposure to a phorbol ester. Additionally, CYTIP associates with SNX27 (sorting nexin 27) and helps to coordinate trafficking and signaling complexes. Up-regulation of CYTIP is observed in maturing dendritic cells, suggesting a possible role in developmentally-controlled cell adhesion.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  B31; CASP; Cbp HE; CYBR; CYTHIP; Cytip; CYTIP_HUMAN; Cytohesin binder and regulator; Cytohesin-associated scaffolding protein; Cytohesin-binding protein HE; Cytohesin-interacting protein; HE antibody Pleckstrin Homology Sec7 and Coiled-Coil Domains Binding Protein; Pleckstrin homology Sec7 and coiled-coil domains-binding protein.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PSCDBP/CYTIP  
• Gene symbol
  CYTIP
• Short name
  Anti-PSCDBP/CYTIP
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  PSCDBP/CYTIP Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  cytohesin 1 interacting protein, B3-1 and CASP and CYBR and CYTHIP and HE and PSCDBP, CYTIP and IDBG-72874 and ENSG00000115165 and 9595, protein binding, nuclei, Cytip and IDBG-171958 and ENSMUSG00000026832 and 227929, CYTIP and IDBG-641611 and ENSBTAG00000008329 and 540450

Gene info

• Identity
  HGNC:9506
• Gene
  CYTIP
• Long gene name
  cytohesin 1 interacting protein
• Synonyms gene
  • PSCDBP
• Synonyms gene name
  • pleckstrin homology, Sec7 and coiled-coil domains, binding protein
• Synonyms
  • B3-1
  • HE
  • CYBR
  • CASP
  • CYTHIP
• Synonyms name
  • cytohesin binding protein HE
  • cytohesin binder and regulator
• GenBank acession
  • L06633
• Locus
  2q24.1
• Discovery year
  1999-07-19
• Entrez gene record
  9595
• Pubmed identfication
  • 18926288
  • 10343115
  • 11867758
  • 20530790
  • 21562043
• RefSeq identity
  • NM_004288
• Classification
  • PDZ domain containing
• VEGA ID
  OTTHUMG00000154551

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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