RAR alpha Antibody

• Catalog number
  bs-0251R
• Price
  Please ask
• Size
  0.1ml

• Long name
  RAR alpha Primary Polyclonal Antibody
• Also known as
  RAR alpha PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  RAR alpha
• Specificity
  This is a highly specific antibody against RAR alpha.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  410-462/462
• Subcellular location
  Cytoplasm, Nucleus
• Source
  OVA conjugated synthetic peptide derived from mouse Retinoic acid Receptor Alpha
• Gene ID number
  19401
• Swiss Prot
  P11416
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  RAR; Nr1b1; RARalpha1; Retinoic acid receptor alpha; RAR-alpha; Nuclear receptor subfamily 1 group B member 1; Rara
• Description
  The Anti-RAR alpha is a α- or alpha protein sometimes glycoprotein present in blood.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  RAR   alpha  
• Gene symbol
  RARA, PRAM1, RAB40B, RAB40A
• Short name
  Anti-RAR alpha
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  RAR alpha Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:9864
• Gene
  RARA
• Long gene name
  retinoic acid receptor alpha
• Synonyms gene name
  • retinoic acid receptor, alpha
• Synonyms
  • RAR
  • NR1B1
• GenBank acession
  • X06538
• Locus
  17q21.2
• Discovery year
  1988-06-09
• Entrez gene record
  5914
• Pubmed identfication
  • 2825036
  • 8244378
• Classification
  • Retinoic acid receptors
• VEGA ID
  OTTHUMG00000133328
• Locus Specific Databases
  • LRG_1070

Gene info

• Identity
  HGNC:30091
• Gene
  PRAM1
• Long gene name
  PML-RARA regulated adaptor molecule 1
• Synonyms
  • PML-RAR
• GenBank acession
  • BC028012
• Locus
  19p13.2
• Discovery year
  2005-07-04
• Entrez gene record
  84106
• Pubmed identfication
  • 11301322
  • 15572693
• RefSeq identity
  • NM_032152
• VEGA ID
  OTTHUMG00000167924

Gene info

• Identity
  HGNC:18284
• Gene
  RAB40B
• Long gene name
  RAB40B, member RAS oncogene family
• Synonyms
  • SEC4L
  • RAR
• GenBank acession
  • U05227
• Locus
  17q25.3
• Discovery year
  2002-02-22
• Entrez gene record
  10966
• Pubmed identfication
  • 11697911
• Classification
  • RAB, member RAS oncogene GTPases
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000177806

Gene info

• Identity
  HGNC:18283
• Gene
  RAB40A
• Long gene name
  RAB40A, member RAS oncogene family
• Synonyms
  • RAR2A
  • Rar-2
• GenBank acession
  • AF132748
• Locus
  Xq22.2
• Discovery year
  2002-02-22
• Entrez gene record
  142684
• Pubmed identfication
  • 11697911
• Classification
  • RAB, member RAS oncogene GTPases
• VEGA ID
  OTTHUMG00000022100
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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