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Stock availabilitIn Stock
In Stock
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CAS number
172889-27-9
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Description
Src kinase inhibitor
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Molecular weight
301,8 g/mol
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Primary research fields
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other name
3-(4-chlorophenyl) 1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C15H16ClN5
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Origin
Synthetic
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Purity pourcentage
≥98% (TLC)
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Soluble in
Soluble in DMSO (25 mg/ml)
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Physical appearance
Off-white solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Acute Toxicity: Oral, Category 3 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301: Toxic if swallowed. Precautionary statements: P264: Wash {hands} thoroughly after handling. P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P330: Rinse mouth
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PubChem number
4878
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Scientific context
PP2 is a selective inhibitor of Src-family tyrosine kinases. PP2 has been shown to inhibit Lck, FynT, and phosphorylation of focal adhesion kinase (FAK) and potently inhibits Hck, Lck (p56) and Fyn (p59). PP2 displays > 10000-fold selectivity over ZAP-70 and JAK2.
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Bibliography
1. Hanke J.H., et al. (1996) J. Biol. Chem. 271(2): 695–701. 2. Liu Y., et al. (1999). Chem. & Biol. 6(9): 671–678.
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Release date
1-Oct-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of PP2 (SIH-470), a Src family kinase inhibitor. CAS #: 172889-27-9. Molecular Formula: C15H16ClN5. Molecular Weight: 301.8 g/mol. Chemical structure of PP2, a Src family kinase inhibitor (SIH-470). CAS # 172889-27-9. Molecular Formula: C15H16ClN5.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.005
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
