PAC-1

Short description

Procaspase-3 activator
Research Area s

Cancer, Cell Cycle, Apoptosis, Caspases, Cell Signaling, Neuroscience
Alternative Name s

4-(Phenylmethyl)-1-piperazineacetic acid [[2-hydroxy-3-(2-propenyl)phenyl]-methylene]hydrazide
Category

Small Molecules
Product Type

Activator
CAS No

315183-21-2
MolecularFormula

C23H28N4O2
Molecular Weight

392.5
Source

Synthetic
Purity

>98% (HPLC); NMR (Conforms)
Solubility

May be dissolved in DMSO (35 mg/ml); or ethanol (15 mg/ml)
Appearance

Off-White powder
Storage Temperature

-20ºC
Shipping Temperature

Shipped Ambient
Field of Use

For in vitro research use only.
Gross Weight kg

0.25
Net Weight g

0.005

Gene target

PAC-1
Gene symbol

DUSP2, PACC1, ADCYAP1R1, GLYR1, PSMG1, KLF6, IGHVII-1-1, MIR1-1, TRUND-NNN8-1, TRUND-NNN7-1
Short name

PAC-1
Alternative name

PAC-1

Identity

HGNC:25593
Gene

PACC1
Long gene name

proton activated chloride channel 1
Synonyms gene
- C1orf75
- TMEM206
Synonyms gene name
- chromosome 1 open reading frame 75
- transmembrane protein 206
Synonyms
- FLJ10874
- PAC
GenBank acession
- AK024066
Locus

1q32.3
Discovery year

2005-05-19
Entrez gene record

55248
Pubmed identfication
- 30417481
- 31318332
RefSeq identity
- NM_018252
VEGA ID

OTTHUMG00000036751

Identity

HGNC:242
Gene

ADCYAP1R1
Long gene name

ADCYAP receptor type I
Synonyms gene name
- adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
Synonyms
- PAC1
- PACAPR
- PAC1R
Synonyms name
- PACAP receptor 1
- pituitary adenylate cyclase-activating polypeptide type 1 receptor
Locus

7p14.3
Discovery year

1994-05-18
Entrez gene record

117
Pubmed identfication
- 7902709
RefSeq identity
- NM_001118
Classification
- Vasoactive intestinal peptide family receptors
VEGA ID

OTTHUMG00000023884

Identity

HGNC:3043
Gene

PSMG1
Long gene name

proteasome assembly chaperone 1
Synonyms gene
- DSCR2
Synonyms gene name
- Down syndrome critical region gene 2
- proteasome (prosome, macropain) assembly chaperone 1
Synonyms
- c21-LRP
- LRPC21
- PAC1
GenBank acession
- AJ006291
Locus

21q22.2
Discovery year

1999-09-17
Entrez gene record

8624
Pubmed identfication
- 10872820
- 17189198
RefSeq identity
- NM_003720
VEGA ID

OTTHUMG00000066034

Identity

HGNC:5670
Gene

IGHVII-1-1
Long gene name

immunoglobulin heavy variable (II)-1-1 (pseudogene)
Synonyms gene name
- immunoglobulin heavy variable (II)-1-1
- immunoglobulin heavy variable (II)-1-1 pseudogene
Synonyms
- IGHV(II)-1-1
GenBank acession
- AB019441
Locus

14q32.33
Discovery year

2000-04-17
Entrez gene record

28377
RefSeq identity
- NG_001019
Classification
- Immunoglobulin heavy locus at 14q32.33
VEGA ID

OTTHUMG00000152325