Plumbagin

  • Catalog number
    2290-250
  • Price
    Please ask
  • Size
    250 mg
  • Alternative_name
    5-Hydroxy-2-methyl-1,4-naphthalened­ione
  • Description
    A quinonoid constituent isolated from the root of Plumbago zeylanica. Displays anticarcinogenic, antiatherosclerotic, and antimicrobial effects as well as anticancer and antiproliferation properties in a variety of cell lines and animal models. Induces G2/M and autophagy in breast cancer cells by inhibiting Akt/mTOR pathway. Also potently inhibits histone acetyltransferase (HAT) activity in vivo. Plumbagin specifically inhibits p300-mediated acetylation of p53 but not the acetylation by p300/CREB-binding protein associated factor, PCAF, in vivo.
  • CAS Number
    481-42-5
  • Structure Available
    Yes
  • Peptide sequence
    No
  • Salt Form
    No
  • Molecular Formula
    C₁₁H₈O₃
  • Molecular Weight
    188.18
  • Cell Permeable
    Yes
  • Purity
    ≥98%
  • Solubilities
    DMSO (~20 mg/ml) or EtOH (~10 mg/ml)
  • Handling
    Protect from air and light
  • Tag Line
    A potent histone acetyltransferase (HAT) inhibitor
  • Storage Condition
    -20 ̊C
  • Shipping Condition
    gel pack
  • Shelf Life
    36 months
  • MDL Number
    MFCD00001682
  • PubChem CID
    10205
  • SMILES
    CC1=CC(=O)C2=C(C1=O)C=CC=C2O
  • InChi
    InChI=1S/C11H8O3/c1-6-5-9(13)10-7(11(6)14)3-2-4-8(10)12/h2-5,12H,1H3
  • InChi Key
    VCMMXZQDRFWYSE-UHFFFAOYSA-N
  • MSDS Available
    Yes
  • Gene target
  • Short name
    Plumbagin
  • Alternative name
    Plumbagin
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