Plumbagin
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Catalog number2290-250
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PricePlease ask
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Size250 mg
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Alternative_name5-Hydroxy-2-methyl-1,4-naphthalenedione
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DescriptionA quinonoid constituent isolated from the root of Plumbago zeylanica. Displays anticarcinogenic, antiatherosclerotic, and antimicrobial effects as well as anticancer and antiproliferation properties in a variety of cell lines and animal models. Induces G2/M and autophagy in breast cancer cells by inhibiting Akt/mTOR pathway. Also potently inhibits histone acetyltransferase (HAT) activity in vivo. Plumbagin specifically inhibits p300-mediated acetylation of p53 but not the acetylation by p300/CREB-binding protein associated factor, PCAF, in vivo.
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CAS Number481-42-5
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Structure AvailableYes
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Peptide sequenceNo
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Salt FormNo
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Molecular FormulaC₁₁H₈O₃
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Molecular Weight188.18
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Cell PermeableYes
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Purity≥98%
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SolubilitiesDMSO (~20 mg/ml) or EtOH (~10 mg/ml)
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HandlingProtect from air and light
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Tag LineA potent histone acetyltransferase (HAT) inhibitor
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Storage Condition-20 ̊C
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Shipping Conditiongel pack
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Shelf Life36 months
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MDL NumberMFCD00001682
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PubChem CID10205
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SMILESCC1=CC(=O)C2=C(C1=O)C=CC=C2O
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InChiInChI=1S/C11H8O3/c1-6-5-9(13)10-7(11(6)14)3-2-4-8(10)12/h2-5,12H,1H3
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InChi KeyVCMMXZQDRFWYSE-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short namePlumbagin
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Alternative namePlumbagin
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