PINX1 Antibody
-
Catalog numberR32303
-
PricePlease ask
-
Size0.1mg
-
-
CategoryAntibody
-
Concentration0.5mg/ml if reconstituted with 0.2ml sterile DI water
-
FormAntigen affinity purified
-
ConjugationUnconjugated
-
ClonePolyclonal antibody
-
Recognised antigenPINX1
-
Host animalRabbit (Oryctolagus cuniculus)
-
ClonalityPolyclonal (rabbit origin)
-
Species reactivityHuman (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
-
Tested applicationsWB
-
Recommended dilutionsWestern blot: 0.1-0.5ug/ml
-
NotesOptimal dilution of the PINX1 antibody should be determined by the researcher.
-
Intented useThis PINX1 antibodyis to be used only for research purposes and not for diagnostics..
-
UniprotQ96BK5
-
PurityAntigen affinity
-
DescriptionPINX1, also known as PIN2 interacting protein 1, is a telomerase inhibitor and a possible tumor suppressor. It is mapped to 8p23. Over-expression of PINX1 results in decreased telomerase activity, telomere shortening, and induction of crisis. Reduction of PINX1 leads to an increase in telomerase activity and elongation of telomeres. PINX1 differs from other proteins that regulate telomere length in that it acts on telomerase while other proteins adjust telomere length without affecting telomerase activity. The PINX1 budding yeast orthologue Gnop1 inhibits telomerase by isolating the uncomplexed TERT protein so that it cannot associate with the telomerase template RNA, which prevents telomerase from being assembled. However, in humans, PINX1 impedes already assembled telomerase.
-
ImmunogenAmino acids DHIKVQVKNNHLGLGATINNEDNWIAHQDD of human PINX1 were used as the immunogen for the PINX1 antibody.
-
StorageAfter reconstitution, the PINX1 antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
-
PropertiesIf you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translationanticorps
-
Gene target
-
Gene symbolPINX1-DT, PINX1
-
Short nameAnti-PINX1
-
TechniqueAntibody, antibodies against human proteins, antibodies for
-
IsotypeRabbit IgG
-
Alternative nameAntibodies to PINX1
-
Alternative techniqueantibodies
-
Gene info
-
Identity
-
Gene
-
Long gene namePINX1 divergent transcript
-
Locus
-
Discovery year2021-03-22
-
Entrez gene record
-
RefSeq identity
-
Classification
- Divergent transcripts
Gene info
-
Identity
-
Gene
-
Long gene namePIN2 (TERF1) interacting telomerase inhibitor 1
-
Synonyms gene name
- PIN2/TERF1 interacting telomerase inhibitor 1
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2010-04-26
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- G-patch domain containing
- SSU processome
- MicroRNA protein coding host genes
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data