PINK1 (N-terminal) - Blocking Peptide

• Catalog number
  X2774B
• Price
  Please ask
• Size
  50 μg

• Category
  Proteins & Peptides
• Long description
  This peptide is the immunogen used to make Cat # X2759P. _x000B__x000B_Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6). A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.
• Antibody come from
  Recombinant protein derived from the carboxy terminus of the calreticulin protein fused to KLH.
• Other description
  Provided as solution in phosphate buffered saline with 0.08% sodium azide.
• Clone
  not specified
• Antigen antibody binding interaction
  PINK1 (N-terminal) - Blocking Peptide
• Antibody is raised in
  see techfile
• Antibody s reacts with
  Blocking Peptide to Cat # X2759P
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  No Data Available
• Application
  Blocking Peptide
• Antibody s suited for
  Antibody can be used for Western blotting (1:1000-1:5000 dilution) and immunofluorescence (1:50 dilution). Optimal concentration should be evaluated by serial dilutions. Suitable for use against recombinant proteins conjugated to OVA, GST, His tags and other.
• Storage
  -20ºC
• Relevant references
  1. Kageyama, S., et al. 'Urinary calreticulin in the diagnosis of bladder urothelial carcinoma.' Int. J. Urol. 2009, 16, 481-486_x000B__x000B_2. Silerova, M., et al. 'Characterization, molecular cloning and localization of calreticulin in Eisenia fetida earthworms.' Gene 2007, 397, 169-177_x000B__x000B_3. Souto-Padron, T., et al. 'Immunocytochemical localisation of calreticulin in Trypanosoma cruzi.' Histochem. Cell Biol. 2004, 122, 563-569
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Test
  You can block the antibody by the specific target amino acid sequence of peptide.
• Properties
  blocking peptide
• Description
  Peptides short amino acid chains or epitopes or blocking antagonists. The shortest peptides are dipeptides, consisting of 2 amino acids joined by a single peptide bond, followed by tripeptides, tetra peptides, ... till polypeptides that are long, continuous, and unbranched synthetic peptide chains. These biological oligomers and polymers can be Solid-phase peptide synthesis (SPPS), or in continue produced for custom peptide synthesis projects. The High-efficiency solid phase peptide synthesis (HE-SPPS) is give very low production costs.

• Gene target
  PINK1  
• Gene symbol
  PINK1-AS, PINK1
• Short name
  PINK1 (N-terminal) - Blocking Peptide
• Technique
  blocking peptide, Blocking, peptide, blocking peptides, nordc made this blocking amino acid sequence or peptide to block the gene target in a volume of 1. For western blot it is often requested to block your antibody and to see the band of the analyzed protein disappear. This is called a negative control by blocking the WB antibody. peptides
• Isotype
  not specified
• Label
  unlabeled
• Alternative name
  phosphatase and tensin homolog induced putative kinase 1 (N-terminal) - inhibiting short protein sequence
• Alternative technique
  control, peptides
• Alternative to gene target
  PTEN induced putative kinase 1, PINK1 and IDBG-92922 and ENSG00000158828 and 65018, transferase activity, nuclei, Pink1 and IDBG-199773 and ENSMUSG00000028756 and 68943, PINK1 and IDBG-645657 and ENSBTAG00000006084 and 510683

Gene info

• Identity
  HGNC:38872
• Gene
  PINK1-AS
• Long gene name
  PINK1 antisense RNA
• Synonyms gene
  • PINK1-AS1
• Synonyms gene name
  • PINK1 antisense RNA 1 (non-protein coding)
  • PINK1 antisense RNA (non-protein coding)
• Synonyms
  • FLJ00387
  • PINK1AS
  • naPINK1
• GenBank acession
  • AK090466
• Locus
  1p36.12
• Discovery year
  2010-08-19
• Pubmed identfication
  • 17362513
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000002840

Gene info

• Identity
  HGNC:14581
• Gene
  PINK1
• Long gene name
  PTEN induced kinase 1
• Synonyms gene
  • PARK6
• Synonyms gene name
  • Parkinson disease (autosomal recessive) 6
  • PTEN induced putative kinase 1
• Synonyms
  • BRPK
• GenBank acession
  • AB053323
• Locus
  1p36.12
• Discovery year
  2001-02-08
• Entrez gene record
  65018
• Pubmed identfication
  • 24751536
  • 11494141
  • 15349860
  • 14607334
• RefSeq identity
  • NM_032409
• Classification
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000002841
• Locus Specific Databases
  • Global Variome shared LOVD

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