Pifithrin mu , Hsp70 inhibitor

• Catalog number
  SIH-325-50MG
• Price
  Please ask
• Size
  50 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  64984-31-2
• Description
  Hsp70 inhibitor
• Molecular weight
  181,2 g/mol
• Primary research fields
  Cancer, Heat Shock
• Other name
  2-Phenylethynesulfonamide, PFTµ
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C8H7NO2S
• Origin
  Synthetic
• Purity pourcentage
  >98%
• Soluble in
  Soluble in ethanol (110 mM) and in DMSO (110 mM)
• Physical appearance
  White to off-white solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Phrases: H302-H315-H319-H335 Precautionary Phrases: P261-P305 + P351 + P338
• PubChem number
  327653
• Scientific context
  Selectively interacts with HSP70 and disrupts its association with co-chaperones and substrate proteins. It induces apoptosis and is cell permeable. Also, inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at more.
• Bibliography
  1. Leu J.L., et al. (2009) Mol. Cell. 36: 15.
• Release date
  16-May-2011
• PubMed number
  25026551|23050124
• Tested applications
  In vitro inhibition|HSP70 inhibitor assay
• Tested reactivity
  Human|Mouse
• Representative figure link
• Representative figure legend
  Chemical structure of Pifithrin mu (SIH-325), a Hsp70 inhibitor. CAS #: 64984-31-2. Molecular Formula: C8H7NO2S. Molecular Weight: 181.2 g/mol. Chemical structure of Pifithrin mu , a Hsp70 inhibitor (SIH-325). CAS # 64984-31-2. Molecular Formula: C8H7NO2S.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.05
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Pifithrin   Hsp70   inhibitor  
• Short name
  Pifithrin mu , Hsp70 inhibitor
• Alternative name
  Pifithrin mu , Hsp70 suppressor

Similar products