Picropodophyllotoxin

Picropodophyllotoxin is available 4 times from Biovision labs

2765-1 | Picropodophyllotoxinsize: 2X1 mg | 364.51 USD

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2765-5 | Picropodophyllotoxinsize: 5 mg | 552.46 USD

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2765-5 | Picropodophyllotoxin for cell activationsize: 5 mg | 471.59 USD

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2765-1 | Picropodophyllotoxin for cell activationsize: 1 mg | 161.75 USD

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  • Description
    A potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF1R) which is non-competitive with ATP. Displays no activity at IR, EGFR, FGFR or PDGFR. Inhibits IGF1R autophosphorylation IC₅₀ ~ 1 nM. Displays antiproliferative activity in numerous tumor cell lines, IC₅₀ = 0.05 - 15 mM. Exhibits antiangiogenic activitiy.
  • Peptide sequence
    N/A
  • CAS number
    477-47-4
  • Molecular weight
    414.41
  • Category
    Biochemicals
  • Other name
    (5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro­-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7­]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one;  NSC 36407, PPP, Picropodophyllin
  • Molecular formula
    C₂₂H₂₂O₈
  • Physical appearance
    White solid
  • Supplied with
    N/A
  • Is this a salt?
    No
  • Is it cell-permeable?
    Y
  • Purification
    ≥97% by TLC
  • Reconstitute instructions
    DMSO (~ 40 mg/ml)
  • Storage condition
    -20°C
  • Shipping condition
    Gel Pack
  • Maximum time for storage
    36 months
  • Storage instructions
    Protect from light and moisture
  • Alternate Name/Synonyms
    (5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro­-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7­]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one;  NSC 36407, PPP, Picropodophyllin
  • Appearance
    White solid
  • Formulation
    N/A
  • CAS Number
    477-47-4
  • Molecular Formula
    C₂₂H₂₂O₈
  • Molecular Weight
    414.41
  • Purity
    ≥97% by TLC
  • Solubility/Reconstitution Instructions
    DMSO (~ 40 mg/ml)
  • Handling
    Protect from light and moisture
  • Tagline
    A potent insulin-like growth factor 1 receptor (IGF1R) inhibitor
  • Storage Temp.
    -20°C
  • Shipping Conditions
    Gel Pack
  • Shelf Life
    36 months
  • MDL Number
    MFCD01742647
  • PubChem CID
    72435
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