TSC2 Antibody (phospho-S1421)
-
Catalog number
F48782-0.08ML
-
Price
Please ask
-
Size
0.08 ml
-
-
Category
Antibody
-
Concentration
In 1X PBS, pH 7.4, with 0.09% sodium azide
-
Form
Antigen affinity purified
-
Conjugation
Unconjugated
-
Clone
Polyclonal antibody
-
Recognised antigen
TSC2 (phospho-S1421)
-
Host animal
Rabbit (Oryctolagus cuniculus)
-
Clonality
Polyclonal (rabbit origin)
-
Species reactivity
Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
-
Tested applications
DB, ELISA
-
Recommended dilutions
Dot blot: 1:500
-
Notes
Titration of the phospho-TSC2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
-
Intented use
This phospho-TSC2 antibodyis to be used only for research purposes and not for diagnostics..
-
Uniprot
Q61037
-
Purity
Antigen affinity
-
Description
In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Specifically stimulates the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth (By similarity).
-
Immunogen
This phospho-TSC2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS1421 of mouse TSC2.
-
Storage
Aliquot the phospho-TSC2 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
-
Properties
If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translation
anticorps
-
Gene target
-
Gene symbol
TSC2
-
Short name
Anti-TSC2 (phospho-S1421)
-
Technique
Antibody, antibodies against human proteins, antibodies for
-
Isotype
Rabbit Ig
-
Alternative name
Antibodies to TSC2 (phospho-S1421)
-
Alternative technique
antibodies
-
Alternative to gene target
tuberous sclerosis 2, LAM and PPP1R160 and TSC4, TSC2 and IDBG-9819 and ENSG00000103197 and 7249, 14-3-3 protein binding, nuclei, Tsc2 and IDBG-147651 and ENSMUSG00000002496 and 22084, TSC2 and IDBG-635000 and ENSBTAG00000020617 and 504985
-
Gene info
-
Identity
-
Gene
-
Long gene name
TSC complex subunit 2
-
Synonyms gene
-
Synonyms gene name
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year
1989-05-25
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- TSC complex
- Armadillo like helical domain containing
- Protein phosphatase 1 regulatory subunits
-
VEGA ID
-
Locus Specific Databases
MeSH Data
-
Name
-
Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Similar products