PARK8 Antibody (LRRK2)
-
Catalog numberF50110-0.08ML
-
PricePlease ask
-
Size0.08 ml
-
-
CategoryAntibody
-
ConcentrationIn 1X PBS, pH 7.4, with 0.09% sodium azide
-
FormAntigen affinity purified
-
ConjugationUnconjugated
-
ClonePolyclonal antibody
-
Recognised antigenPARK8 (LRRK2)
-
Host animalRabbit (Oryctolagus cuniculus)
-
ClonalityPolyclonal (rabbit origin)
-
Species reactivityHuman (Homo sapiens), Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
-
Tested applicationsWB, IHC, ELISA
-
Recommended dilutionsWestern blot: 1:1000,IHC (Paraffin): 1:10-1:50
-
NotesTitration of the LRRK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
-
Intented useThis LRRK2 antibodyis to be used only for research purposes and not for diagnostics..
-
UniprotQ5S007
-
PurityAntigen affinity
-
DescriptionParkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson's disease identified to date. LRRK2, a genetic mutation, was recently found linked to about 5 percent of inherited cases of Parkinson's disease. By high-resolution recombination mapping and candidate gene sequencing in 46 families, 6 disease-segregating mutations (5 missense and 1 putative splice site mutation). It may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism. LRRK2 belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains.
-
ImmunogenA portion of amino acids 878-909 from the human protein was used as the immunogen for this LRRK2 antibody.
-
StorageAliquot the LRRK2 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
-
PropertiesIf you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translationanticorps
-
Gene target
-
Gene symbolLRRK2, LRRK2-DT
-
Short nameAnti-PARK8 (LRRK2)
-
TechniqueAntibody, antibodies against human proteins, antibodies for
-
IsotypeRabbit Ig
-
Alternative nameAntibodies to PARK8 (LRRK2)
-
Alternative techniqueantibodies
-
Alternative to gene targetleucine-rich repeat kinase 2, LRRK2 and IDBG-27257 and ENSG00000188906 and 120892, transferase activity, Extracellular, Lrrk2 and IDBG-175625 and ENSMUSG00000036273 and 66725, LRRK2 and IDBG-633456 and ENSBTAG00000016260 and 535652
-
Gene info
-
Identity
-
Gene
-
Long gene nameleucine rich repeat kinase 2
-
Synonyms gene
-
Synonyms gene name
- Parkinson disease (autosomal dominant) 8
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2004-10-22
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Armadillo like helical domain containing
- ROCO family
-
VEGA ID
-
Locus Specific Databases
Gene info
-
Identity
-
Gene
-
Long gene nameLRRK2 divergent transcript
-
Locus
-
Discovery year2019-08-16
-
Entrez gene record
-
Classification
- Divergent transcripts
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data