PAK1/PAK2/PAK3 (T423/T402/T421) Antibody

• Catalog number
  bs-3316R
• Price
  Please ask
• Size
  0.1ml

• Long name
  PAK1/PAK2/PAK3 (T423/T402/T421) Antibody
• Also known as
  PAK1/PAK2/PAK3 (T423/T402/T421) Antibody
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  PAK1 + PAK2 + PAK3 T423 + T402 + T421
• Specificity
  This is a highly specific antibody against PAK1 + PAK2 + PAK3 T423 + T402 + T421.
• Modification s
  Phosphorylation
• Modification site s
  T423 + T402 + T421
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human PAK1 around the phosphorylation site of Thr423
• Gene ID number
  5058
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  In mammals, there are several identified isoforms of p21 Activated Protein Kinases or PAKs: PAK1 and PAK3 are mostly brain specific, while PAK2 is expressed ubiquitously. Mutations of the gene coding for PAK3 are associated with X linked mental retardation and PAK3 is a key regulator of synapse formation and plasticity in the hippocampus. PAK3 is thought to play a key role in regulation of cell shape and motility as well as cell death. P21-activated kinase (PAK) is actually a family of serine/threonine protein kinases, members of which are activated by small molecular weight GTPases. The three most common isoforms are PAK 1, PAK 2, and PAK 3 (also known as alpha PAK, gamma PAK, and beta PAK, respectively). These kinases contain numerous regulatory elements that trigger diverse signaling processes such as those initiated by activated GTPases, interaction with Src homology 3 (SH3) domains, and caspase mediated proteolytic cleavage. Autophosphorylation of serine 141 (serine 144 for PAK 1 and serine 139 PAK 3), catalyzed by Cdc42, is required for activation of PAK.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  PAK1 + PAK2 + PAK3 phospho T423 + T402 + T421; PAK1 + PAK2 + PAK3 phospho Thr423 + Thr402 + Thr421; Pak2phospho T402; Pak1phospho T423; PAK1phospho T402; PAK2phospho T423; PAKalpha; serine/threonine-protein kinase PAK 1; p21 activated kinase 1; PAK alpha; Paka; PAKalpha; Protein kinase MUK2; STE20 homolog yeast; Alpha PAK; p21/Cdc42/Rac1 activated kinase 1; CB422; EC 2.7.11.1; Gamma PAK; hPAK65; Kinase; p21 CDKN1A-activated kinase 2a; p21 activated kinase 2; p21 protein Cdc42/Rac-activated kinase 2; p21 protein Cdc42 Rac activated kinase 2; p21-activated kinase, 65-KD; p21-activated protein kinase I; p21CDKN1A activated kinase 2; p58; p65PAK; PAK 2; PAK65; PAKgamma; S6 H4 kinase; Serine threonine protein kinase PAK 2; Serine/threonine-protein kinase PAK 3; p21-activated kinase 3; PAK-3; Beta-PAK; PAK1_HUMAN; PAK2_HUMAN.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PAK1/PAK2/PAK3   T423/T402/T421  
• Gene symbol
  PAK1, PAK2, PAK3, PKN1, ARHGEF7
• Short name
  Anti-PAK1 + PAK2 + PAK3 T423 + T402 + T421
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  PAK1/PAK2/PAK3 (T423/T402/T421) Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  p21 protein (Cdc42/Rac)-activated kinase 1, PAKalpha, PAK1 and IDBG-65610 and ENSG00000149269 and 5058, transferase activity, nuclei, Pak1 and IDBG-199974 and ENSMUSG00000030774 and 18479, PAK1 and IDBG-642220 and ENSBTAG00000010191 and 533729

Gene info

• Identity
  HGNC:8590
• Gene
  PAK1
• Long gene name
  p21 (RAC1) activated kinase 1
• Synonyms gene name
  • p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)
  • p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)
  • p21 protein (Cdc42/Rac)-activated kinase 1
• Synonyms name
  • STE20 homolog, yeast
• GenBank acession
  • U51120
• Locus
  11q13.5-q14.1
• Discovery year
  1997-12-05
• Entrez gene record
  5058
• Pubmed identfication
  • 8805275
  • 9533029
• RefSeq identity
  • NM_002576
• VEGA ID
  OTTHUMG00000165138

Gene info

• Identity
  HGNC:8591
• Gene
  PAK2
• Long gene name
  p21 (RAC1) activated kinase 2
• Synonyms gene name
  • p21 (CDKN1A)-activated kinase 2
  • p21 protein (Cdc42/Rac)-activated kinase 2
• Synonyms
  • PAK65
  • PAKgamma
• Synonyms name
  • S6/H4 kinase
• GenBank acession
  • U24153
• Locus
  3q29
• Discovery year
  1998-03-25
• Entrez gene record
  5062
• Pubmed identfication
  • 7744004
  • 7618083
• RefSeq identity
  • NM_002577
• VEGA ID
  OTTHUMG00000155534

Gene info

• Identity
  HGNC:8592
• Gene
  PAK3
• Long gene name
  p21 (RAC1) activated kinase 3
• Synonyms gene
  • MRX30
  • MRX47
• Synonyms gene name
  • mental retardation, X-linked 47
  • p21 (CDKN1A)-activated kinase 3
  • p21 protein (Cdc42/Rac)-activated kinase 3
• Synonyms
  • hPAK3
  • bPAK
• GenBank acession
  • AF068864
• Locus
  Xq23
• Discovery year
  1998-03-25
• Entrez gene record
  5063
• Pubmed identfication
  • 8826460
  • 9731525
• RefSeq identity
  • NM_002578
• VEGA ID
  OTTHUMG00000022202

Gene info

• Identity
  HGNC:9405
• Gene
  PKN1
• Long gene name
  protein kinase N1
• Synonyms gene
  • PRKCL1
• Synonyms gene name
  • protein kinase C-like 1
• Synonyms
  • DBK
  • PRK1
  • PKN
  • MGC46204
  • PAK1
• GenBank acession
  • S75546
• Locus
  19p13.12
• Discovery year
  1997-10-10
• Entrez gene record
  5585
• Pubmed identfication
  • 9570957
• RefSeq identity
  • NM_002741
  • NM_213560
• Classification
  • C2 domain containing protein kinases
  • AGC family kinases
• VEGA ID
  OTTHUMG00000039611

Gene info

• Identity
  HGNC:15607
• Gene
  ARHGEF7
• Long gene name
  Rho guanine nucleotide exchange factor 7
• Synonyms gene name
  • Rho guanine nucleotide exchange factor (GEF) 7
• Synonyms
  • KIAA0142
  • PIXB
  • DKFZp761K1021
  • Nbla10314
  • DKFZp686C12170
  • BETA-PIX
  • COOL1
  • P85SPR
  • P85
  • P85COOL1
  • P50BP
  • PAK3
  • P50
• Synonyms name
  • SH3 domain-containing proline-rich protein
  • PAK-interacting exchange factor beta
• GenBank acession
  • D63476
• Locus
  13q34
• Discovery year
  2001-11-21
• Entrez gene record
  8874
• Pubmed identfication
  • 9207241
  • 9726964
• RefSeq identity
  • NM_001113511
• Classification
  • Pleckstrin homology domain containing
  • Dbl family Rho GEFs
• VEGA ID
  OTTHUMG00000017357

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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