PAK1/PAK2/PAK3 (T423/T402/T421) Antibody
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Catalog numberbs-3316R
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PricePlease ask
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Size0.1ml
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Long namePAK1/PAK2/PAK3 (T423/T402/T421) Antibody
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Also known asPAK1/PAK2/PAK3 (T423/T402/T421) Antibody
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CategoryPrimary Antibodies
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ConjugationUnconjugated
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Target AntigenPAK1 + PAK2 + PAK3 T423 + T402 + T421
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SpecificityThis is a highly specific antibody against PAK1 + PAK2 + PAK3 T423 + T402 + T421.
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Modification sPhosphorylation
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Modification site sT423 + T402 + T421
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ClonalityPolyclonal antibody
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Clone numberPolyclonal antibody
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Concentration1ug per 1ul
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SourceKLH conjugated synthetic phosphopeptide derived from human PAK1 around the phosphorylation site of Thr423
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Gene ID number5058
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Tested ApplicationsWB, IHC-P, IF(IHC-P)
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Recommended dilutionsWB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
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Cross reactivityHuman, Mouse, Rat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigenIn mammals, there are several identified isoforms of p21 Activated Protein Kinases or PAKs: PAK1 and PAK3 are mostly brain specific, while PAK2 is expressed ubiquitously. Mutations of the gene coding for PAK3 are associated with X linked mental retardation and PAK3 is a key regulator of synapse formation and plasticity in the hippocampus. PAK3 is thought to play a key role in regulation of cell shape and motility as well as cell death. P21-activated kinase (PAK) is actually a family of serine/threonine protein kinases, members of which are activated by small molecular weight GTPases. The three most common isoforms are PAK 1, PAK 2, and PAK 3 (also known as alpha PAK, gamma PAK, and beta PAK, respectively). These kinases contain numerous regulatory elements that trigger diverse signaling processes such as those initiated by activated GTPases, interaction with Src homology 3 (SH3) domains, and caspase mediated proteolytic cleavage. Autophosphorylation of serine 141 (serine 144 for PAK 1 and serine 139 PAK 3), catalyzed by Cdc42, is required for activation of PAK.
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Purification methodThis antibody was purified via Protein A.
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Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Synonym namesPAK1 + PAK2 + PAK3 phospho T423 + T402 + T421; PAK1 + PAK2 + PAK3 phospho Thr423 + Thr402 + Thr421; Pak2phospho T402; Pak1phospho T423; PAK1phospho T402; PAK2phospho T423; PAKalpha; serine/threonine-protein kinase PAK 1; p21 activated kinase 1; PAK alpha; Paka; PAKalpha; Protein kinase MUK2; STE20 homolog yeast; Alpha PAK; p21/Cdc42/Rac1 activated kinase 1; CB422; EC 2.7.11.1; Gamma PAK; hPAK65; Kinase; p21 CDKN1A-activated kinase 2a; p21 activated kinase 2; p21 protein Cdc42/Rac-activated kinase 2; p21 protein Cdc42 Rac activated kinase 2; p21-activated kinase, 65-KD; p21-activated protein kinase I; p21CDKN1A activated kinase 2; p58; p65PAK; PAK 2; PAK65; PAKgamma; S6 H4 kinase; Serine threonine protein kinase PAK 2; Serine/threonine-protein kinase PAK 3; p21-activated kinase 3; PAK-3; Beta-PAK; PAK1_HUMAN; PAK2_HUMAN.
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PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolPAK1, PAK2, PAK3, PKN1, ARHGEF7
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Short nameAnti-PAK1 + PAK2 + PAK3 T423 + T402 + T421
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TechniqueAntibody, antibodies against human proteins, antibodies for
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HostRabbit (Oryctolagus cuniculus)
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IsotypeImmunoglobulin G (IgG)
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Alternative namePAK1/PAK2/PAK3 (T423/T402/T421) Antibody
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Alternative techniqueantibodies
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Alternative to gene targetp21 protein (Cdc42/Rac)-activated kinase 1, PAKalpha, PAK1 and IDBG-65610 and ENSG00000149269 and 5058, transferase activity, nuclei, Pak1 and IDBG-199974 and ENSMUSG00000030774 and 18479, PAK1 and IDBG-642220 and ENSBTAG00000010191 and 533729
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Gene info
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Identity
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Gene
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Long gene namep21 (RAC1) activated kinase 1
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Synonyms gene name
- p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)
- p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)
- p21 protein (Cdc42/Rac)-activated kinase 1
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Synonyms name
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GenBank acession
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Locus
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Discovery year1997-12-05
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namep21 (RAC1) activated kinase 2
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Synonyms gene name
- p21 (CDKN1A)-activated kinase 2
- p21 protein (Cdc42/Rac)-activated kinase 2
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-03-25
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namep21 (RAC1) activated kinase 3
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Synonyms gene
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Synonyms gene name
- mental retardation, X-linked 47
- p21 (CDKN1A)-activated kinase 3
- p21 protein (Cdc42/Rac)-activated kinase 3
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-03-25
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameprotein kinase N1
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Synonyms gene
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Synonyms gene name
- protein kinase C-like 1
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Synonyms
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GenBank acession
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Locus
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Discovery year1997-10-10
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C2 domain containing protein kinases
- AGC family kinases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameRho guanine nucleotide exchange factor 7
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Synonyms gene name
- Rho guanine nucleotide exchange factor (GEF) 7
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-11-21
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Pleckstrin homology domain containing
- Dbl family Rho GEFs
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data