PAK3 (Ser139) Antibody, ALEXA FLUOR 555
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Catalog numberbs-1655R-A555
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PricePlease ask
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Size100ul
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Long namePAK3 (Ser139) Polyclonal Antibody, ALEXA FLUOR 555 Conjugated
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Also known asAnti-PAK3 Ser139 PAb ALEXA FLUOR 555
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CategoryConjugated Primary Antibodies
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Conjugated withALEXA FLUOR® 555
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Host OrganismRabbit (Oryctolagus cuniculus)
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Target AntigenPAK3 Ser139
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SpecificityThis is a highly specific antibody against PAK3 Ser139.
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ModificationPhosphorylation
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Modification SiteSer139
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ClonalityPolyclonal
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ClonePolyclonal antibody
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Concentration1ug per 1ul
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SourceKLH conjugated synthetic phosphopeptide derived from human PAK3 around the phosphorylation site of (Ser139)
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Gene ID Number5063
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Tested applicationsIF(IHC-P)
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Recommended dilutionsIF(IHC-P)(1:50-200)
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CrossreactivityHuman, Mouse, Rat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the antigenThe p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.P21-activated kinase (PAK) is actually a family of serine/threonine protein kinases, members of which are activated by small molecular weight GTPases. The three most common isoforms are PAK 1, PAK 2, and PAK 3 (also known as alpha PAK, gamma PAK, and beta PAK, respectively). These kinases contain numerous regulatory elements that trigger diverse signaling processes such as those initiated by activated GTPases, interaction with Src homology 3 (SH3) domains, and caspase mediated proteolytic cleavage. Autophosphorylation of serine 141 (serine 144 for PAK 1 and serine 139 PAK 3), catalyzed by Cdc42, is required for activation of PAK.
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PurificationPurified by Protein A.
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Storage conditionsStore this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
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Excitation emission553nm/568nm
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SynonymsPAK3_HUMAN; Beta PAK; bPAK; CDKN1A; hPAK3; Mental retardation X linked 30; MRX30; MRX47; Oligophrenin 3; OPHN3; p21 activated kinase 3; p21 CDKN1A activated kinase 3; PAK-3; PAK3 p21 protein Cdc42/Rac-activated kinase 3; PAK3beta; Pak65alpha; Pak65beta; Serine threonine protein kinase PAK 3; Stk4.
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PropertiesFor facs or microscopy Alexa 1 conjugate. Very high photo stable ALEXA conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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ConjugationAlexa Fluor, ALEXA FLUOR 555
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French translationanticorps
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Gene target
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Gene symbolPAK3, ARHGEF7
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Short nameAnti-PAK3 Ser139
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeImmunoglobulin G (IgG)
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LabelALEXA FLUOR 555
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Alternative namePAK3 (Ser139) Polyclonal Antibody, ALEXA FLUOR 555
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namep21 (RAC1) activated kinase 3
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Synonyms gene
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Synonyms gene name
- mental retardation, X-linked 47
- p21 (CDKN1A)-activated kinase 3
- p21 protein (Cdc42/Rac)-activated kinase 3
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-03-25
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameRho guanine nucleotide exchange factor 7
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Synonyms gene name
- Rho guanine nucleotide exchange factor (GEF) 7
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-11-21
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Pleckstrin homology domain containing
- Dbl family Rho GEFs
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data