Rabbit Polyclonal (IgG) to Human TP53 / p53

• Catalog number
  MBS246785
• Price
  Please ask
• Size
  0.05 mL

• Products_type
  Antibody
• Products_short_name
  [TP53 / p53]
• Products_name_syn
  [Anti-TP53 / p53 Antibody (Acetyl-Lys379) IHC-plus; TP53; BCC7; Cellular tumor antigen p53; p53; TRP53; p53 tumor suppressor; Phosphoprotein p53; Antigen NY-CO-13; Tumor protein p53; Tumor suppressor p53; LFS1; Human TP53; p53]
• Other_names
  [cellular tumor antigen p53 isoform a; Cellular tumor antigen p53; cellular tumor antigen p53; antigen NY-CO-13; tumor protein 53; phosphoprotein p53; p53 tumor suppressor; mutant tumor protein 53; transformation-related protein 53; tumor protein p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53]
• Products_gene_name
  [TP53]
• Products_gene_name_syn
  [p53]
• Other_gene_names
  [TP53; TP53; P53; BCC7; LFS1; TRP53; P53]
• Clonality
  Polyclonal
• Reactivity
  Human, Mouse, Rat
• Specificity
  p53 (Acetyl-Lys379) Antibody detects endogenous levels of total p53 protein only when acetylated at lysine379.
• Purity
  Immunoaffinity Purified
• Form
  PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
• Concentration
  1 mg/ml
• Storage_stability
  Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
• Tested_application
  Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), ELISA (EIA)
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• About
  Immunoglobulin gamma, IgG, mouse monoclonal H&L chain clones or rabbit, goat polyclonal antibodies have 4 parts. There are 2 heavy chains, 2 light chains. The IgG antibody has 2 antigen binding sites. They represent 70% or more of serum antibodies. This antibody can be antigen purified or protein A or G purified. For storage sodium azide is added or you can call us to request azide free antibody preparations. These will need colder storage temperatures. Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera. Rabbits are used for polyclonal antibody production by MyBioSource. Rabbit antibodies are very stable and can be stored for several days at room temperature. MyBioSource adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
• Group
  Polyclonals and antibodies
• Latin name
  Oryctolagus cuniculus

• Gene target
  TP53   p53  
• Gene symbol
  TP53
• Short name
  Rabbit Polyclonal (IgG) TP53 / p53
• Technique
  Polyclonal, Rabbit, IgG, IgGs, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Host
  Rabbit, Rabbits
• Isotype
  IgG, IgG
• Species
  Human, Humans
• Alternative name
  production species: rabbit polyclonal (Immunoglobulin G) to H. sapiens tumor protein p53 / p53
• Alternative technique
  polyclonals, rabbit-anti, immunoglobulins
• Alternative to gene target
  tumor protein p53, BCC7 and LFS1 and P53 and TRP53, TP53 and IDBG-26364 and ENSG00000141510 and 7157, MDM2/MDM4 family protein binding, nuclei, Trp53 and IDBG-191036 and ENSMUSG00000059552 and 22059, TP53 and IDBG-635147 and ENSBTAG00000001069 and 281542

Gene info

• Identity
  HGNC:11998
• Gene
  TP53
• Long gene name
  tumor protein p53
• Synonyms
  • p53
  • LFS1
• Synonyms name
  • Li-Fraumeni syndrome
• GenBank acession
  • AF307851
• Locus
  17p13.1
• Discovery year
  1986-01-01
• Entrez gene record
  7157
• Pubmed identfication
  • 6396087
  • 3456488
  • 2047879
• RefSeq identity
  • NM_000546
• VEGA ID
  OTTHUMG00000162125
• Locus Specific Databases
  • IARC TP53 Mutation Database
  • p53 UMD TP53 mutation database
  • Database of Germline p53 Mutations
  • MUTP53LOAD, Mutant p53 Loss Of Activity Database
  • LRG_321

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