p95 NBS1 (Ser343) Antibody, ALEXA FLUOR 555
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Catalog number
bs-3718R-A555
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Price
Please ask
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Size
100ul
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Long name
p95 NBS1 (Ser343) Polyclonal Antibody, ALEXA FLUOR 555 Conjugated
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Also known as
Anti-p95 NBS1 Ser343 PAb ALEXA FLUOR 555
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Category
Conjugated Primary Antibodies
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Conjugated with
ALEXA FLUOR® 555
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Host Organism
Rabbit (Oryctolagus cuniculus)
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Target Antigen
p95 NBS1 Ser343
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Specificity
This is a highly specific antibody against p95 NBS1 Ser343.
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Modification
Phosphorylation
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Modification Site
Ser343
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Clonality
Polyclonal
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Clone
Polyclonal antibody
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Concentration
1ug per 1ul
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Immunogen range
320-370/754
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Subcellular location
Nucleus
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Source
KLH conjugated synthetic phosphopeptide derived from human NBS1 around the phosphorylation site of Ser343
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Gene ID Number
4683
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Swiss Prot
O60934
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Tested applications
IF(IHC-P)
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Recommended dilutions
IF(IHC-P)(1:50-200)
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Crossreactivity
Human, Rat
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Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the antigen
Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
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Purification
Purified by Protein A.
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Storage conditions
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
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Excitation emission
553nm/568nm
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Synonyms
ATV; NBS; P95; NBS1; AT-V1; AT-V2; Nibrin; Cell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1; NBN
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Properties
For facs or microscopy Alexa 1 conjugate. Very high photo stable ALEXA conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Conjugation
Alexa Fluor, ALEXA FLUOR 555
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French translation
anticorps
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Gene target
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Gene symbol
NLRP2, NBN
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Short name
Anti-p95 NBS1 Ser343
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Technique
Antibody, antibodies against human proteins, antibodies for
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Isotype
Immunoglobulin G (IgG)
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Label
ALEXA FLUOR 555
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Alternative name
p95 NBS1 (Ser343) Polyclonal Antibody, ALEXA FLUOR 555
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Alternative technique
antibodies
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Gene info
Gene info
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Identity
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Gene
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Long gene name
nibrin
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Synonyms gene
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Synonyms gene name
- Nijmegen breakage syndrome 1 (nibrin)
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Synonyms
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GenBank acession
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Locus
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Discovery year
1997-11-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MRN complex
- BRCA1 C complex
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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