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Synonyms
p38, mitogen-activated protein kinase 11
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Alternative_names
p38, mitogen-activated protein kinase 11
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Description
Involved in a wide variety of cellular processes
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Recombinant
Yes
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Source
Baculovirus (Sf9 insect cells)
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Purity by SDS PAGE
≥90%
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Assay
SDS-PAGE
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Activity Specifications test method
The specific activity of P38BETA was determined to be 123 nmol /min/mg as per activity assay protocol.
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Molecular Weight
71.0 kDa
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Storage Temp
-80°C
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Shipping
dry ice
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Shelf Life
12 months
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Concentration
0.1mg/ml
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Appearance
Liquid
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Physical form description
Recombinant protein stored in 50mM Tris-HCl, pH 7.5, and 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
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Background Information
p38-β is a member of the p38 MAP kinase family and is activated by both proinflammatory cytokines and environmental stress (1). The p38-β is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase (2). Alternatively spliced transcript variants encoding the same protein have been observed.
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Handling
Centrifuge the vial prior to opening.
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Usage
For Research Use Only! Not to be used in humans
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